1583-66-0

Basic information

• Product Name: 5-FLUOROPHTALIC ACID
• Synonyms: 5-FLUORO-ISOPHTHALIC ACID;5-FLUOROPHTALIC ACID;Nsc302311;5-Fluorobenzene-1,3-dicarboxylic acid
• CAS NO: 1583-66-0
• Molecular Formula: C₈H₅FO₄
• Molecular Weight: 184.12
• Product Categories: Fluorine series
• Mol File: 1583-66-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 295-297℃
• Boiling Point: 407.7 °C at 760 mmHg
• Flash Point: 200.4 °C
• Appearance: /
• Density: 1.551
• Vapor Pressure: 2.23E-07mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.19±0.10(Predicted)
• CAS DataBase Reference: 5-FLUOROPHTALIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUOROPHTALIC ACID(1583-66-0)
• EPA Substance Registry System: 5-FLUOROPHTALIC ACID(1583-66-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1583-66-0(Hazardous Substances Data)

Usage

Uses

5-Fluoroisophthalic Acid is a useful research chemical.

InChI:InChI=1/C8H5FO4/c9-6-2-4(7(10)11)1-5(3-6)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 461-97-2 3,5-dimethylfluorobenzene 
• 108-69-0 3,5-dimethylaminoaniline 
• 518070-19-4 3-fluoro-5-methylbenzoic acid 

Downstream Products

• 20330-80-7 5-fluoroisophthalamide 
• 17449-48-8 dimethyl 5-fluoroisophthalate 
• 19254-86-5 (5-fluoro-1,3-phenylene)dimethanol 

Relevant articles and documents

Effect of Substituents at the 5-Position on the First and Second Dissociation Constants of Isophthalic Acid

The dissociation constants of benzoic acid and 20 of its meta- or para-substituted derivatives and of isophthalic acid and ten of its 5-substituted derivatives have been measured in 50 wtpercent aqueous methanol.The Hammett ρ value for benzoic acid is 1.28; for isophthalic acid the ρ values are 1.21 (pK1) and 1.20 (pK2).The ?meta values for hydroxy and acetoxy are -0.01 and +0.29, respectively, in this system.Values for ?meta for CO2H and CO2- are calculated to be +0.28 and -0.20, respectively; however there are indications that these values are not completely structure-independent.

COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The present invention provides novel beta-secretase inhibitors of the general formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.