1583285-93-1Relevant articles and documents
INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES
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Paragraph 0088; 00105, (2015/03/28)
Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.
Rhodium-catalyzed intermolecular C-H silylation of arenes with high steric regiocontrol
Chen, Cheng,Hartwig, John F.
, p. 853 - 857 (2014/03/21)
Regioselective C-H functionalization of arenes has widespread applications in synthetic chemistry. The regioselectivity of these reactions is often controlled by directing groups or steric hindrance ortho to a potential reaction site. Here, we report a catalytic intermolecular C-H silylation of unactivated arenes that manifests very high regioselectivity through steric effects of substituents meta to a potential site of reactivity. The silyl moiety can be further functionalized under mild conditions but is also inert toward many common organic transformations, rendering the silylarene products useful building blocks. The remote steric effect that we observe results from the steric properties of both the rhodium catalyst and the silane.
