15878-08-7

Basic information

• Product Name: 4-Chloro-3-Methyl-1H-pyrazole
• Synonyms: Pyrazole,4-chloro-3(or 5)-methyl- (6CI,7CI); Pyrazole, 4-chloro-3-methyl- (8CI);4-Chloro-3-methylpyrazole
• CAS NO: 15878-08-7
• Molecular Formula: C₄H₅ClN₂
• Molecular Weight: 116.5489
• Mol File: 15878-08-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 218.1°Cat760mmHg
• Flash Point: 106.4°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 0.189mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.27±0.50(Predicted)
• CAS DataBase Reference: 4-Chloro-3-Methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-Methyl-1H-pyrazole(15878-08-7)
• EPA Substance Registry System: 4-Chloro-3-Methyl-1H-pyrazole(15878-08-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37-60
• TSCA: No
• Hazardous Substances Data: 15878-08-7(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-Methyl-1H-pyrazole is a chemical compound with the molecular formula C4H6ClN3. It is a chlorinated and methylated derivative of pyrazole, which is a heterocyclic aromatic compound. This chemical is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various compounds. It is also used as an intermediate for the production of herbicides, pesticides, and pharmaceutical drugs. Additionally, 4-Chloro-3-Methyl-1H-pyrazole has been studied for its potential biological activities, including its antimicrobial and anti-inflammatory properties. However, its toxicological and environmental effects should be carefully evaluated due to its chlorinated nature.

InChI:InChI=1/C4H5ClN2/c1-3-4(5)2-6-7-3/h2H,1H3,(H,6,7)

Upstream product

• 1453-58-3 3-Methylpyrazole 
• 7791-25-5 sulfuryl dichloride 
• 60-29-7 diethyl ether 
• 56-23-5 tetrachloromethane 
• 7782-50-5 chlorine 

Downstream Products

• 15878-44-1 1,3-Dimethyl-4-chlor-pyrazol 
• 84703-26-4 1,5-dimethyl-4-chloropyrazole 
• 1319197-05-1 2-(4-chloro-3-methyl-1H-pyrazol-1-yl)-6-methylaniline 
• 84547-87-5 4-chloro-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Enzymatic Halogenation of Pyrazoles and Pyridine Derivatives

Pyrazole, 1-methylpyrazole and 3-methylpyrazole are chlorinated by the enzyme chloroperoxidase from Caldariomyces fumago, in the presence of potassium chloride and hydrogen peroxide at pH 2.7, yielding the corresponding 4-chloro derivatives in good yields.A 4H-pyrazole is proposed as an intermediate in this reaction. 2-Aminopyridine was converted regiospecifically by the same enzyme into 2-amino-3-chloropyridine, and 8-hydroxyquinoline gave its 5,7-dibromo-derivatives in very good yield when bromide ion was used as halide substrate.