158817-18-6

Basic information

• Product Name: bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite
• Synonyms: bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite
• CAS NO: 158817-18-6
• Molecular Weight: 613.927
• Mol File: 158817-18-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite(158817-18-6)
• EPA Substance Registry System: bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite(158817-18-6)

Safety Data

• Hazardous Substances Data: 158817-18-6(Hazardous Substances Data)

Upstream product

• 77772-21-5 tert-butyl α-(methyldiphenylsilyl)acetate 
• 144-79-6 chloromethyldiphenylsilane 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 
• 40438-48-0 diphenylmethylsilylethylethanol 

Downstream Products

• 1027946-87-7 Phosphorous acid tert-butyl ester bis-[2-(methyl-diphenyl-silanyl)-ethyl] ester 
• 158817-11-9 N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine 
• 158817-12-0 N^α-(benzyloxycarbonyl)-O-phosphono>tyrosine benzyl ester 
• 1027397-66-5 Phosphorous acid bis-[2-(methyl-diphenyl-silanyl)-ethyl] ester 1-methyl-3-phenyl-propyl ester 
• 1026544-75-1 Phosphorous acid bis-[2-(methyl-diphenyl-silanyl)-ethyl] ester phenethyl ester 
• 1026356-97-7 Phosphorous acid methyl ester bis-[2-(methyl-diphenyl-silanyl)-ethyl] ester 

Relevant articles and documents

Use of Bis N,N-Dialkylphosphoramidites for the Synthesis of Phosphate Monoesters

The bis N,N-dialkylphosphoramidites 7a and b and bis N,N-dialkylphosphoramidites 6a and b have been prepared by reaction of the N,N-dialkylphosphorochloridites 5a and b with the appropriate 2-(trialkylsilyl)ethanol.In the presence of 1H-tetrazole, the phosphoramidites 6a, b and 7a, b phosphorylated MeOH, PhCH2OH, PhCH2CH2OH, Me(PhCH2CH2(CHOH, 2,3,4,5,6-penta-O-benzyl-myo-inositol and ButOH, to give the phosphites 8a-h.Without isolation, these were oxidized to the corresponding phosphate triesters 9a-h with m-chloroperbenzoic acid.Treatment of the triesters 9a-h with tetrabutylammonium fluoride removes only 2-(trialkylsilyl)ethyl group to give the diesters 10a-h, whereas treatment with a solution of hydrofluoric acid in acetonitrile-water gives the phosphate monoesters 11a-e.