158984-84-0Relevant articles and documents
Electrochemical Approach for Direct C-H Phosphonylation of Unprotected Secondary Amine
Huang, Min,Dai, Jie,Cheng, Xu,Ding, Mengning
supporting information, p. 7759 - 7762 (2019/10/11)
Direct α-phosphonylation of an unprotected secondary amine in a single step is of practical importance to amino phophophates. However, this protocol is limited due to the high redox barrier of unprotected amine. In this paper, we report C-H phosphonylation of an unprotected secondary amine via an electrochemical approach in the presence of catalytic carboxylate salt. This metal-free and exogenous oxidant-free method furnishes diverse target molecules with satisfactory yield under mild reaction conditions. Successful application of the protocol in a gram-scale experiment demonstrates the potential utility for further functionalization.
T-type calcium channel inhibitor
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Paragraph 0215, (2016/11/02)
The present invention addresses the problem of providing novel compounds that have T-type voltage-gated calcium channel-blocking activity and are useful particularly in treating pain, chronic kidney disease, and atrial fibrillation. Provided are novel tri
As opioid receptor antagonists or inverse agonists of the novel compounds
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Paragraph 0490; 0491, (2016/10/08)
Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.