15911-11-2Relevant articles and documents
Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc-rter: Initial homology model
Matti, Afnan A.,Mirzaei, Joseph,Rudolph, John,Smith, Stephen A.,Newell, Jayme L.,Patel, Sarjubhai A.,Braden, Michael R.,Bridges, Richard J.,Natale, Nicholas R.
, p. 5931 - 5935 (2013)
Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.
Base- and copper-catalysed condensation of primary activated nitro compounds with enolisable compounds
Trogu, Elena,Cecchi, Luca,De Sarlo, Francesco,Guideri, Luca,Ponticelli, Fabio,Machetti, Fabrizio
experimental part, p. 5971 - 5978 (2010/03/01)
Primary nitro compounds have not been employed as nitrile oxide precursors in reactions with active methylene compounds because the reagents commonly used as dehydrating agents also react with these dipolarophiles. However, the Cu II-catalysed
[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents
Giovannoni, Maria Paola,Vergelli, Claudia,Ghelardini, Carla,Galeotti, Nicoletta,Bartolini, Alessandro,Dal Piaz, Vittorio
, p. 1055 - 1059 (2007/10/03)
A number of [(3-chlorophenyl)piperazinylpropyl]pyridazinones and the corresponding isoxazolopyridazinones, showing the arylpiperazinyl substructure present in very potent antinociceptive agents reported in the literature, were synthesized and tested for t