159190-45-1

Basic information

• Product Name: L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
• Synonyms: N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE;L-NIL DIHYDROCHLORIDE;L-NIL HCL;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2);L-Lysine ω-acetamidine dihydrochloride
• CAS NO: 159190-45-1
• Molecular Formula: C8H19Cl2N3O2
• Molecular Weight: 260.16
• Product Categories: Nitric Oxide
• Mol File: 159190-45-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 369 °C at 760 mmHg
• Flash Point: 177 °C
• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE(159190-45-1)
• EPA Substance Registry System: L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE(159190-45-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36
• WGK Germany: 3
• Hazardous Substances Data: 159190-45-1(Hazardous Substances Data)

Usage

Description

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE, also known as L-NIL, is a relatively selective inhibitor of inducible nitric oxide synthase (iNOS). It is characterized by its ability to effectively inhibit iNOS both in vitro and in vivo, with IC50 values of 0.4-3.3 μM for iNOS, compared to 8-38 and 17-92 μM for endothelial NOS (eNOS) and neuronal NOS (nNOS), respectively. L-NIL has been instrumental in demonstrating the critical role of iNOS in the immune response to infections, such as those caused by the protozoan Leishmania major.

Uses

Used in Pharmaceutical Research:
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE is used as a research tool for studying the effects of iNOS inhibition on various cellular processes. It is particularly useful in investigating the role of iNOS in immune responses, inflammation, and other related pathways.
Used in Cell Biology:
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE is used as an iNOS inhibitor to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine. This application helps researchers understand the role of iNOS in cellular signaling and metabolism.
Used in Hepatocyte Studies:
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE is used as an iNOS inhibitor for studying its effects on leptin-induced inflammation in hepatocytes. This application aids in understanding the role of iNOS in liver inflammation and its potential implications in liver diseases.
Used in Bone Marrow Mesenchymal Stromal Cell (BMSC) Research:
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE is used as an iNOS inhibitor to block the production of nitric oxide in mice BMSCs. This application is crucial for studying the role of iNOS in bone marrow function and its potential impact on stem cell biology and regenerative medicine.

Biochem/physiol Actions

Selective inhibitor of inducible nitric oxide synthase (iNOS).