15933-07-0Relevant articles and documents
A New Synthesis of α-Keto Esters and Acids
Nimitz, Jonathan S.,Mosher, Harry S.
, p. 211 - 213 (1981)
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Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and evaluation of their influence on melanin synthesis in murine B16 cells
Nie, Li Fei,Huang, Guozheng,Bozorov, Khurshed,Zhao, Jiangyu,Niu, Chao,Sagdullaev, Shamansur S.,Aisa, Haji A.
, p. 43 - 50 (2018)
A diversity-oriented synthesis of amide-containing thieno[2,3-d]pyrimidin-4(3H)-ones is reported. All compounds were tested for their influence on melanin synthesis in murine B16 cells. The azepine fragment in thieno[2,3-d]pyrimidin-4(3H)-one skeleton significantly increases the melanin content.
Tominaga et al.
, p. 830 (1966)
Synthesizing method for dimethyl-3-hydroxy-2,5-dihydrofuran-2-one spice
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Paragraph 0042-0052, (2019/10/23)
The invention discloses a synthesizing method for dimethyl-3-hydroxy-2,5-dihydrofuran-2-one spice, and relates to the technical field of specie synthesis. According to the synthesizing method, the dimethyl-3-hydroxy-2,5-dihydrofuran-2-one is obtained by taking diethyl oxalate as a starting material, preparing 2-oxo-ethyl butyrate through a Grignard reaction in the absence of water and under the protection of nitrogen; cyclizing a required carbon skeleton under the action of potassium carbonate and acetaldehyde to obtain the dimethyl-3-hydroxy-2,5-dihydrofuran-2-one. A reaction solvent and an extracting agent can be used after being recycled; the process flow is reduced; the reaction yield is relatively high.
Design, synthesis, and evaluation of alkyl-quinoxalin-2(1h)-one derivatives as anti-quorum sensing molecules, inhibiting biofilm formation in aeromonas caviae Sch3
Bl?cher, René,Ramírez, Ariel Rodarte,Castro-Escarpulli, Graciela,Curiel-Quesada, Everardo,Reyes-Arellano, Alicia
, (2018/11/30)
With the increasing antibiotic resistance of bacterial strains, alternative methods for infection control are in high demand. Quorum sensing (QS) is the bacterial communication system based on small molecules. QS is enables bacterial biofilm formation and pathogenic development. The interruption of QS has become a target for drug discovery, but remains in the early experimental phase. In this study, we synthesized a set of six compounds based on a scaffold (alkyl-quinoxalin-2(1H)-one), new in the anti-QS of Gram-negative bacteria Aeromonas caviae Sch3. By quantifying biofilm formation, we were able to monitor the effect of these compounds from concentrations of 1 to 100 μM. Significant reduction in biofilm formation was achieved by 3-hexylylquinoxalin-2(1H)-one (11), 3-hexylylquinoxalin-2(1H)-one-6-carboxylic acid (12), and 3-heptylylquinoxalin-2(1H)-one-6-carboxylic acid (14), ranging from 11% to 59% inhibition of the biofilm. This pilot study contributes to the development of anti-QS compounds to overcome the clinical challenge of resistant bacteria strains.
