159439-02-8 Usage
Description
AC-TYR(PO3H2)-GLU-GLU-ILE-GLU, also known as N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, is a peptide ligand that specifically binds to the pp60c-src SH2 domains. It is a short sequence of amino acids that plays a crucial role in cellular signaling processes by interacting with the SH2 domains of proteins.
Uses
Used in Pharmaceutical Industry:
AC-TYR(PO3H2)-GLU-GLU-ILE-GLU is used as a targeting molecule for the development of drugs that modulate the activity of pp60c-src, a non-receptor tyrosine kinase involved in various cellular processes, including cell growth, differentiation, and survival. By targeting the SH2 domains of pp60c-src, this peptide ligand can potentially be used to regulate the kinase's activity, which may have therapeutic implications in the treatment of various diseases, such as cancer.
Used in Research Applications:
AC-TYR(PO3H2)-GLU-GLU-ILE-GLU is used as a research tool for studying the structure, function, and regulation of pp60c-src and its associated signaling pathways. This peptide ligand can be employed in various experimental setups, such as binding assays, competition experiments, and structural studies, to gain insights into the molecular mechanisms underlying the regulation of pp60c-src and its role in cellular signaling.
Used in Drug Delivery Systems:
Similar to gallotannin, AC-TYR(PO3H2)-GLU-GLU-ILE-GLU can potentially be incorporated into drug delivery systems to improve the targeting and efficacy of therapeutic agents that modulate pp60c-src activity. By using this peptide ligand as a targeting moiety, drug delivery systems can be designed to specifically deliver therapeutic agents to cells expressing pp60c-src, thereby enhancing the treatment's specificity and reducing potential side effects.
Biological Activity
Phosphopeptide ligand for the src SH2 domain (IC 50 = 1 μ M). Blocks src interactions with EGFR and FAK.
Check Digit Verification of cas no
The CAS Registry Mumber 159439-02-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,4,3 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 159439-02:
(8*1)+(7*5)+(6*9)+(5*4)+(4*3)+(3*9)+(2*0)+(1*2)=158
158 % 10 = 8
So 159439-02-8 is a valid CAS Registry Number.
