1595091-97-6

Basic information

• Product Name: C₄₁H₅₁N₅O₈S
• CAS NO: 1595091-97-6
• Molecular Weight: 773.951
• Mol File: 1595091-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₁H₅₁N₅O₈S(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₁H₅₁N₅O₈S(1595091-97-6)
• EPA Substance Registry System: C₄₁H₅₁N₅O₈S(1595091-97-6)

Safety Data

• Hazardous Substances Data: 1595091-97-6(Hazardous Substances Data)

Upstream product

• 88217-68-9 (4-morpholinyl)acetic acid 1,1-dimethylethyl ester 
• 89531-58-8 N-(carboxymethyl)morpholine hydrochloride 

Relevant articles and documents

Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum

The plasmepsins are specific aspartic proteases of the malaria parasite and a potential target for developing new antimalarial agents. Our previously reported peptidomimetic plasmepsin inhibitor with modified 2-aminoethylamino substituent, KNI-10740, was tested against chloroquine sensitive Plasmodium falciparum, D6, to be highly potent, however, the inhibitor exhibited about 5 times less activity against multi-drug resistant parasite (TM91C235). We hypothesized the potency reduction resulted from structural similarity between 2-aminoethylamino substituent of KNI-10740 and chloroquine. Then, we modified the moiety and finally identified compound 15d (KNI-10823), that could avoid drug-resistant mechanism of TM91C235 strain.