159517-86-9Relevant articles and documents
Carbohydrate-Catalyzed Enantioselective Alkene Diboration: Enhanced Reactivity of 1,2-Bonded Diboron Complexes
Fang, Lichao,Yan, Lu,Haeffner, Fredrik,Morken, James P.
supporting information, p. 2508 - 2511 (2016/03/12)
Catalytic enantioselective diboration of alkenes is accomplished with readily available carbohydrate-derived catalysts. Mechanistic experiments suggest the intermediacy of 1,2-bonded diboronates.
Rational synthesis of contra-thermodynamic spiroacetals by reductive cyclizations
Takaoka, Leo R.,Buckmelter, Alexandre J.,LaCruz, Thomas E.,Rychnovsky, Scott D.
, p. 528 - 529 (2007/10/03)
A synthesis of spiroacetals was developed using a reductive cyclization strategy that leads stereoselectively to spiroacetals with a single anomeric stabilization. The method begins with the synthesis of spiro ortho esters. The ortho ester is converted to a cyano acetal. Reductive lithiation of the cyano acetal generates an axial dialkoxylithium reagent, and intramolecular cyclization produces a new ring with retention of configuration. The strategy is convergent and produces complex spiro acetals in only a few steps. The method will be useful in the synthesis of natural products and will facilitate the synthesis of previously inaccessible contra-thermodynamic acetals. Copyright
A Difference CD Method for Determining Absolute Stereochemistry of Acyclic 1,2,4-Triols
Mori, Yuji,Furukawa, Hiroshi
, p. 6725 - 6738 (2007/10/02)
A general method based on difference circular dichroic (DIF CD) spectroscopy for assigning the absolute configuration of 1,2,4-triol is presented.Four possible stereoisomers of 6-heptene-1,2,4-triol were prepared and served as models to develop the procedure.The sign of the DIF CD Cotton effect is correlated to the absolute configuration of the C2 position.