15952-20-2

Basic information

• Product Name: Benzoxazole, 6-chloro-2-phenyl-
• CAS NO: 15952-20-2
• Molecular Formula: C13H8ClNO
• Molecular Weight: 229.666
• Mol File: 15952-20-2.mol
• Article Data: 32

Chemical Properties

• CAS DataBase Reference: Benzoxazole, 6-chloro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoxazole, 6-chloro-2-phenyl-(15952-20-2)
• EPA Substance Registry System: Benzoxazole, 6-chloro-2-phenyl-(15952-20-2)

Safety Data

• Hazardous Substances Data: 15952-20-2(Hazardous Substances Data)

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 28443-50-7 2-amino-5-chlorophenol 
• 53442-08-3 N-(4-chlorophenyl)benzamide oxime 
• 106-47-8 4-chloro-aniline 
• 698-16-8 benzohydroximoyl chloride 
• 100-52-7 benzaldehyde 
• 55-21-0 benzamide 
• 873-38-1 4-chloro-2-bromoaniline 
• 135364-97-5 tert-butyl benzoyl(tert-butoxycarbonyl)carbamate 
• 611-07-4 5-chloro-2-nitrophenol 
• 98-88-4 benzoyl chloride 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 150-60-7 dibenzyl disulphide 
• 1608-45-3 4-chloro-1,2,-diiodobenzene 

Downstream Products

• 1396008-51-7 2-hydroxy-6-(2-(2-phenylbenzo[d]oxazol-6-yl)ethyl)benzoic acid 
• 1396008-57-3 2,2-dimethyl-5-(2-(2-phenylbenzo[d]oxazol-6-yl)ethyl)-4H-benzo[d][1,3]dioxin-4-one 
• 1396008-56-2 2,2-dimethyl-5-((2-phenylbenzo[d]oxazol-6-yl)ethynyl)-4H-benzo[d][1,3]dioxin-4-one 
• 79108-84-2 6-chloro-2-(2-hydroxyphenyl)benzoxazole 

Relevant articles and documents

Delivering 2-Aryl Benzoxazoles through Metal-Free and Redox-Neutral De-CF3Process

An unexpected cleavage of the Csp3-CF3 bond of CF3-hydrobenzoxazoles has been disclosed, affording a range of 2-aryl benzoxazoles under metal-free and redox-neutral conditions. This transformation has demonstrated broad substrate scope and good compatibility of functional groups. 2-Aryl benzothiazole and 2-aryl benzoimidazole could be smoothly assembled in the same manner. On the basis of preliminary mechanistic studies, base initiated and aromatization driven β-carbon elimination was considered to be the key step for the formation of 2. This reaction offers an alternative, facile, and sustainable route to access important 2-aryl benzoxazole motifs.

Sulfur-Promoted Synthesis of Benzoxazoles from 2-Aminophenols and Aldehydes

Elemental sulfur (S8) was found to be an excellent stoichiometric oxidant to promote oxidative condensation of 2-aminophenols with a wide range of aldehydes, including aliphatic aldehyde such as cyclohexanecarboxaldehyde. The reactions were catalyzed by sodium sulfide in the presence of DMSO as an additive. The benzoxazole products were obtained in satisfactory yields. The reaction conditions could be applied to larger syntheses (10–50 mmol).

Method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions

The invention discloses a method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions. According to the method, glacial aceticacid is taken as a catalyst; at solvent-free room temperature conditions, physical grinding is adopted, reaction of 2-substituted arylamines (2-mercapto arylamine, 2-aminophenol, and o-phenylenediamine) and aromatic aldehydes is carried out using physical grinding. The method is friendly to the environment, is simple in operation, is safe, is low in cost, and is high in efficiency. Compared withthe prior art, the advantages are that: the method is suitable for a large amount of functional groups, yield is high, less by-product is generated, operation is simple, the method is safe, cost is low, and the method is friendly to the environment.