159617-00-2

Basic information

• Product Name: 1-(2-nitrophenyl)-3-heptanone
• Synonyms: 1-(2-nitrophenyl)-3-heptanone
• CAS NO: 159617-00-2
• Molecular Weight: 235.283
• Mol File: 159617-00-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-nitrophenyl)-3-heptanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-nitrophenyl)-3-heptanone(159617-00-2)
• EPA Substance Registry System: 1-(2-nitrophenyl)-3-heptanone(159617-00-2)

Safety Data

• Hazardous Substances Data: 159617-00-2(Hazardous Substances Data)

Upstream product

• 4938-52-7 1-hepten-3-ol 
• 609-73-4 o-nitroiodobenzene 
• 110-62-3 pentanal 
• 159617-01-3 2-butyl-2-<2-(2-nitrophenyl)ethyl>-1,3-dioxolane 

Downstream Products

• 159617-03-5 N-(2-<2-(2-butyl-1,3-dioxolan-2-yl)ethyl>phenyl)-4-methoxybenzamide 
• 159617-04-6 4-methoxy-N-<2-(3-oxoheptyl)phenyl>benzamide 
• 159617-02-4 2-<2-(butyl-1,3-dioxolan-2-yl)ethyl>benzenamine 
• 159617-01-3 2-butyl-2-<2-(2-nitrophenyl)ethyl>-1,3-dioxolane 

Relevant articles and documents

Synthesis of 4-methoxy-N-{2-[3-(methylamino)phenyl}benzamide, and antiarrhythmic compound related to encainide

A ring-opened side product 3, formed during the reduction of a pyridinium precursor to the antiarrhythmic drug, encainide (2), was isolated. The structure of 3 was confirmed by an independent synthesis from o-iodonitrobenzene and 1-hepten-3-ol. The key step was a palladium(II) catalyzed coupling to introduce the 3-oxoheptyl side chain onto the aromatic ring. Synthetic 3 exhibited significant antiarrhythmic activity.