159877-35-7

Basic information

• Product Name: 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine
• Synonyms: 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine;Octahydro-6-(phenylmethyl)-1h-pyrrolo[3,4-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester
• CAS NO: 159877-35-7
• Molecular Formula: C₁₉H₂₈N₂O₂
• Molecular Weight: 316
• Mol File: 159877-35-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 409.1°C at 760 mmHg
• Flash Point: 201.2°C
• Appearance: /
• Density: 1.097g/cm³
• Vapor Pressure: 6.67E-07mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• PKA: 9.25±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine(159877-35-7)
• EPA Substance Registry System: 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine(159877-35-7)

Safety Data

• Hazardous Substances Data: 159877-35-7(Hazardous Substances Data)

Usage

General Description

1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine is a chemical compound with the molecular formula C19H29NO2. It is a bicyclic compound containing a pyrrolopyridine core with a benzyl and tert-butoxycarbonyl (Boc) group attached to it. 1-Boc-6-benzyloctahydropyrrolo[3,4-b]pyridine is commonly used as a building block in organic synthesis and pharmaceutical research. It can be utilized as a protective group for amines and amides, as well as a precursor for the synthesis of various biologically active molecules. Additionally, it is a versatile intermediate in the synthesis of heterocyclic compounds and can be used in the development of new drugs and pharmaceuticals.

InChI:InChI=1/C19H28N2O2/c1-19(2,3)23-18(22)21-11-7-10-16-13-20(14-17(16)21)12-15-8-5-4-6-9-15/h4-6,8-9,16-17H,7,10-14H2,1-3H3

Upstream product

• 128740-14-7 (R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]-nonane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 100-46-9 benzylamine 

Downstream Products

• 159877-36-8 octahydro-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester 
• 1438082-56-4 tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[3,4-b] pyridine-1-carboxylate 
• 1438073-26-7 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 

Relevant articles and documents

Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment

A series of octahydropyrrolo[3,4-c]pyrroles were synthesized and evaluated by orexin 1 and 2 receptor (OX1 & 2R) antagonists assays. Compound 14l with potent OXR antagonist activity and suitable pharmacokinetic behavior was chosen to be investigated in an EEG study, which demonstrated effects of sleep promotion comparable to Suvorexant. Furthermore, the di-fluro substituted analogs exhibited reduced hERG inhibition while maintaining moderate potency.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.