15992-83-3Relevant articles and documents
A highly selective fluorescent sensor for Cd2+ based on a new diarylethene with a 1,8-naphthyridine unit
Zhang, Xiaoxia,Wang, Renjie,Fan, Congbin,Liu, Gang,Pu, Shouzhi
, p. 208 - 217 (2017)
A new asymmetrical photochromic diarylethene has been synthesized by using 1,8-naphthyridine as a functional group and perfluorodiarylethene as photoswitching unit via a peptide bond linkage, and its molecular structure was characterized by single crystal X-ray diffraction analysis. The compound exhibited favorable photochromism upon irradiation with UV/vis light, and its fluorescent behaviour could be efficiently modulated by light, base/acid, and metal ion in THF. The deprotonated derivative of the diarylethene also showed good photochromism, and displayed remarkable “turn-on” fluorescence response during photocyclization process. Furthermore, the diarylethene was highly selective toward Cd2+ with an obvious fluorescent color change from dark to bright green in THF. Finally, a logic circuit was fabricated with four inputs of the combinational stimuli of UV/vis and Cd2+/EDTA, and one output of fluorescence intensity.
Chichibabin Amination of 1,X-Naphthyridines. Nuclear Magnetic Resonance Studies on the ? Adducts of Heterocyclic Systems with Nucleophiles
Haak, Henk J. W. van den,Plas, Henk C. van der,Veldhuizen, Beb van
, p. 2134 - 2137 (1981)
In the amination of 1,X-naphthyridines with potassium amide in liquid ammonia at about -35 to -40 deg C the initial adduct formation is charge controlled.Thus, at these temperatures the site with the lowest electron density is most susceptible for amide attack (C-2 in 1,5-naphthyridine, C-2 in 1,6-naphthyridine, C-2 and C-8 in 1,7-naphthyridine, and C-2 in 1,8-naphthyridine), as proven by NMR spectroscopy.When the temperature was raised to about 10 deg C, the site of addition has been found to change for 1,5- and 1,7-naphthyridine (NMR spectroscopy): from C-2 to C-4 in 1,5-naphthyridine and from C-2 and C-8 to C-8 only in 1,7-naphthyridine.In case of 1,6- and 1,8-naphthyridines no change was observed.Thus, the amination at about 10 deg C is a process which is thermodynamically controlled.The several factors which contribute to the stability of these addition products have been discussed.It has been found that the anionic ? adducts 2(4,8)-aminodihydro-1,X-naphthyridinides can be easily oxidized with potassium permanganate into their corresponding 2(4,8)-amino-1,X-naphthyridines.
Conformational change in the association of a heterocyclic urea derivative forming two intramolecular hydrogen bonds in polar solvent
Kwiatkowski, Adam,Grela, Izabela,O?mia?owski, Borys
, p. 1073 - 1081 (2017/02/10)
The association of a model, heterocyclic compound capable of forming two intramolecular hydrogen bonds was studied with the use of various anionic and neutral species in highly polar solvents, but also, for some of them, in chloroform. The hydrogen bonding of anions was tuned through the substituents present in their structures. This approach was used in distinguishing which part of the bisurea heterocyclic derivative is preferred during complex formation. Neutral counterparts capable of forming three or five hydrogen bonds were also used. Moreover, triple association was probed, suggesting the formation of a complex only in chloroform. DFT computations were helpful in the interpretation of the experimental data related to complicated equilibria. These are based on the energy of rotation about single bonds, energy of interaction and QTAIM-based energies of hydrogen bonds.
TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF ROR? AND THE TREATMENT OF DISEASE
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Paragraph 00198, (2013/12/03)
The invention provides tetrahydro[1,8]naphthyridine and related compounds, pharmaceutical compositions, methods of promoting ROR? activity, increasing the amount of IL-17 in a subject, and treating cancer using such tetrahydro[1,8]naphthyridine and relate
