15996-83-5

Basic information

• Product Name: (1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime
• CAS NO: 15996-83-5
• Molecular Formula: C₉H₈F₃NO
• Molecular Weight: 203.1611
• Mol File: 15996-83-5.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 247.2°C at 760 mmHg
• Flash Point: 103.3°C
• Density: 1.23g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.464
• CAS DataBase Reference: (1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime(15996-83-5)
• EPA Substance Registry System: (1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime(15996-83-5)

Safety Data

• Hazardous Substances Data: 15996-83-5(Hazardous Substances Data)

Usage

Description

(1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime is a chemical compound that belongs to the oxime functional group. It is a pale yellow solid with a molecular formula of C9H9F3NO and a molecular weight of 213.17 g/mol. (1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime is characterized by the presence of a trifluoromethyl and phenyl group, which impart unique chemical and biological properties to the molecule.

Uses

Used in Organic Chemistry:
(1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime is used as a synthetic intermediate in organic chemistry for the synthesis of various biologically active compounds. Its unique structure allows for versatile reactions and transformations, making it a valuable building block in the development of new organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime serves as a key intermediate in the synthesis of potential drug candidates. Its unique chemical properties enable the creation of novel compounds with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Chemical Industry:
(1Z)-1-[4-(trifluoromethyl)phenyl]ethanone oxime is also utilized in the chemical industry for the development of specialty chemicals and materials. Its distinctive structure and reactivity make it suitable for the production of various chemical products with specific applications in different fields.

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 593-56-6 N-methoxylamine hydrochloride 
• 15996-84-6 1-(4-trifluoromethylphenyl)ethylamine 

Downstream Products

• 15996-84-6 1-(4-trifluoromethylphenyl)ethylamine 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 336109-43-4 C₂₁H₁₇F₃NOP 
• 912341-98-1 2,2,2-trifluoro-N-[1-(4-trifluoromethyl-phenyl)-vinyl]-acetamide 
• 177750-09-3 N-(1-(4-(trifluoromethyl)phenyl)vinyl)acetamide 
• 866540-38-7 N-(1-(4-trifluoromethyl)ethylidene)diphenylphosphinamide 
• 1265612-75-6 C₁₁H₁₁BrF₃NO 
• 1257846-21-1 (E)-1-(4-(trifluoromethyl)-phenyl)ethanone O-acetyl oxime 
• 1310320-99-0 N-acetyl-1-methyl-1-(4-trifluoromethylphenyl)allylamine 
• 1335246-80-4 1-[4-(trifluoromethyl)phenyl]ethanone O-(3,5-dinitrophenyl)oxime 
• 1335246-84-8 1-[4-(trifluoromethyl)phenyl]ethanone O-(3-amino-5-nitrophenyl)oxime 
• 1335246-60-0 4-nitro-2-[4-(trifluoromethyl)phenyl]-1-benzofuran-6-amine 
• 1335246-53-1 6-nitro-2-[4-(trifluoromethyl)phenyl]-1H-indol-4-ol 
• 16368-48-2 N-(4-trifluoromethylphenyl)ethanethioamide 

Relevant articles and documents

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

Rhodium(III)-Catalyzed Direct C-H Arylation of Various Acyclic Enamides with Arylsilanes

The stereoselective β-C(sp2)-H arylation of various acyclic enamides with arylsilanes via Rh(III)-catalyzed cross-coupling reaction was illustrated. The methodology was characterized by extraordinary efficacy and stereoselectivity, a wide scope of substrates, good functional group tolerance, and the adoption of environmentally friendly arylsilanes. The utility of this present method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, Rh(III)-catalyzed C-H activation is considered to be the critical step in the reaction mechanism.

Rhodium(iii)-catalyzed asymmetric [4+1] spiroannulations of: O -pivaloyl oximes with α-diazo compounds

Chiral RhIII catalysts can catalyze the asymmetric [4+1] spiroannulation of O-pivaloyl oximes with α-diazo homophthalimides under redox-neutral and acid/base-neutral conditions, leading to formation of chiral spirocyclic imines as a result of C-H activation and N-O cleavage. The reaction proceeded with high efficiency and features broad substrate scope, mild reaction conditions, and high to excellent enantioselectivities. This journal is