16019-31-1

Basic information

• Product Name: 5-ALLYL-4,6-DICHLORO-PYRIMIDINE
• Synonyms: 5-ALLYL-4,6-DICHLORO-PYRIMIDINE;4,6-dichloro-5-(prop-2-en-1-yl)pyriMidine;PyriMidine, 4,6-dichloro-5-(2-propen-1-yl)-;4,6-dichloro-5-(2-propen-1-yl)Pyrimidine
• CAS NO: 16019-31-1
• Molecular Formula: C₇H₆Cl₂N₂
• Molecular Weight: 189.05
• Mol File: 16019-31-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 261℃
• Flash Point: 137℃
• Appearance: /
• Density: 1.31
• Vapor Pressure: 0.0193mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-ALLYL-4,6-DICHLORO-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ALLYL-4,6-DICHLORO-PYRIMIDINE(16019-31-1)
• EPA Substance Registry System: 5-ALLYL-4,6-DICHLORO-PYRIMIDINE(16019-31-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 16019-31-1(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow paint, liquid

InChI:InChI=1/C7H6Cl2N2/c1-2-3-5-6(8)10-4-11-7(5)9/h2,4H,1,3H2

Upstream product

• 16019-30-0 5-(prop-2-en-1-yl)pyrimidine-4,6-diol 
• 16019-30-0 6-hydroxy-5-(2-propen-1-yl)-4(1H)-pyrimidinone 
• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 16019-30-0 5-allyl-6-hydroxy-3H-pyrimidin-4-one 
• 1193-21-1 4,6-dichloropyrimidine 
• 106-95-6 allyl bromide 
• 1426659-18-8 5-(4,6-dichloropyrimidinyl)zinc pivalate 
• 40637-56-7 dimethyl allylmalonate 

Downstream Products

• 16019-33-3 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde 
• 14052-82-5 4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine 
• 1027512-70-4 5-[3-(3-bromo-phenyl)-propyl]-6-chloro-pyrimidin-4-ylamine 
• 1026317-26-9 6-chloro-5-[3-(2-chloro-phenyl)-propyl]-pyrimidin-4-ylamine 
• 454685-51-9 5-[3-(2-chloro-phenyl)-propyl]-6-iodo-pyrimidin-4-ylamine 
• 454685-49-5 5-[3-(3-bromo-phenyl)-propyl]-6-iodo-pyrimidin-4-ylamine 
• 454685-50-8 5-[3-(4-bromo-phenyl)-propyl]-6-iodo-pyrimidin-4-ylamine 
• 1001397-14-3 6-chloro-N-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(2-propen-1-yl)-4-pyrimidinamine 
• 1228504-13-9 (5-allyl-6-chloro-pyrimidin-4-yl)-m-tolyl-amine 

Relevant articles and documents

ATROPISOMERISM FOR ENHANCED KINASE INHIBITOR SELECTIVITY

The invention provides a series of conformationally stable and selective kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly inter

Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors

Many biologically active molecules exist as rapidly interconverting atropisomeric mixtures. Whereas one atropisomer inhibits the desired target, the other can lead to off-target effects. Herein, we study atropisomerism as a possibility to improve the sele

A ring-closing metathesis approach to heterocycle-fused azepines

Heterocycle-fused azepines, an important class of molecular scaffold, are readily synthesised through the ruthenium-catalysed ring-closing metathesis reaction. Although benzo-fused azepines are well documented, heterocycle-fused examples are poorly developed. Herein, a range of five- and six-membered heterocycle-fused azepines are investigated, allowing access to a series of pharmaceutically interesting products.