160231-69-6 Usage
Description
[(1S,2R)-3-[[(4-Nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-phenylmethyl)propyl]carbamic Acid, (3S)-Tetrahydro-3-furanyl Ester is a complex organic compound with a unique molecular structure. It is characterized by its off-white solid appearance and plays a crucial role as an intermediate in the synthesis of Amprenavir, a selective HIV protease inhibitor.
Uses
Used in Pharmaceutical Industry:
[(1S,2R)-3-[[(4-Nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-phenylmethyl)propyl]carbamic Acid, (3S)-Tetrahydro-3-furanyl Ester is used as an intermediate in the synthesis of Amprenavir for its role in inhibiting the replication of the HIV virus. This application is significant in the development of treatments for HIV and AIDS, contributing to the fight against these life-threatening diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 160231-69-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,0,2,3 and 1 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 160231-69:
(8*1)+(7*6)+(6*0)+(5*2)+(4*3)+(3*1)+(2*6)+(1*9)=96
96 % 10 = 6
So 160231-69-6 is a valid CAS Registry Number.
InChI:InChI=1/C25H33N3O8S/c1-18(2)15-27(37(33,34)22-10-8-20(9-11-22)28(31)32)16-24(29)23(14-19-6-4-3-5-7-19)26-25(30)36-21-12-13-35-17-21/h3-11,18,21,23-24,29H,12-17H2,1-2H3,(H,26,30)/t21-,23-,24+/m0/s1
160231-69-6Relevant articles and documents
Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir
Furfine, Eric S.,Baker, Christopher T.,Hale, Michael R.,Reynolds, David J.,Salisbury, Jo A.,Searle, Andy D.,Studenberg, Scott D.,Todd, Dan,Tung, Roger D.,Spaltenstein, Andrew
, p. 791 - 798 (2004)
GW433908 is the water-soluble, phosphate ester prodrug of the human immunodeficiency virus type 1 protease inhibitor amprenavir (APV). A high-yield synthesis of GW433908 is achieved by phosphorylation of the penultimate precursor of APV with phosphorous o
PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE FOSAMPRENAVIR CALCIUM AND ITS INTERMEDIATES
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Paragraph 0051, (2013/07/19)
The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro -3 -furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparat
PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE FOSAMPRENAVIR CALCIUM AND ITS INTERMEDIATES
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Page/Page column 14, (2012/03/27)
The present invention relates to fosamprenavir calcium (la) substantially free of isomer impurity, (3R) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]- 1-benzyl-2-(phosphonooxy)propyl carbamate (lb), and its process for prepar