160233-42-1

Basic information

• Product Name: METHYL (R)-1-TRITYL-2-AZIRIDINECARBOXYLATE
• Synonyms: METHYL (R)-1-TRITYL-2-AZIRIDINECARBOXYLATE;(R)-Methyl 1-tritylaziridine-2-carboxylate;methyl (2R)-1-(triphenylmethyl)aziridine-2-carboxylate
• CAS NO: 160233-42-1
• Molecular Formula: C₂₃H₂₁NO₂
• Molecular Weight: 343.42
• Mol File: 160233-42-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 430.3°Cat760mmHg
• Flash Point: 133.3°C
• Appearance: /
• Density: 1.195g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• PKA: 2.57±0.40(Predicted)
• CAS DataBase Reference: METHYL (R)-1-TRITYL-2-AZIRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (R)-1-TRITYL-2-AZIRIDINECARBOXYLATE(160233-42-1)
• EPA Substance Registry System: METHYL (R)-1-TRITYL-2-AZIRIDINECARBOXYLATE(160233-42-1)

Safety Data

• Hazardous Substances Data: 160233-42-1(Hazardous Substances Data)

Usage

General Description

Methyl (R)-1-trityl-2-aziridinecarboxylate is a chemical compound with the formula C23H21NO3. It is a derivative of aziridine and is commonly used as a reagent in organic synthesis. The compound is characterized by a trityl-protected aziridine ring and a methyl ester functional group. It is widely used in the pharmaceutical and chemical industries as a building block in the synthesis of various organic compounds. The compound is also known for its potential biological activity and has been studied for its potential use as a pharmaceutical intermediate.

InChI:InChI=1/C23H21NO2/c1-26-22(25)21-17-24(21)23(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16,21H,17H2,1H3/t21-,24?/m1/s1

Upstream product

• 116457-91-1 (2R)-3-hydroxy-2-(tritylamino)propanoic acid methyl ester 
• 116457-92-2 O-mesyl-N-trityl-D-serine methyl ester 
• 121-44-8 triethylamine 
• 76-83-5 trityl chloride 
• 160233-40-9 methyl (2S)-N-tritylisoserinate 

Downstream Products

• 113510-53-5 (R)-1-trityl-aziridine-2-carbohydroxamic acid 
• 312-84-5 D-Serine 
• 103539-32-8 (2R)-aziridine-2-carboxylic acid methyl ester 
• 178866-39-2 (-)-(R)-N₁-(triphenylmethyl)aziridine-2-carboxamide 
• 155976-02-6 methyl (2R)-N-(4-methylphenyl)sulfonylaziridine-2-carboxylate 
• 1021495-51-1 methyl (R)-N-(p-nitrobenzenesulfonyl)aziridine-2-carboxylate 
• 1239355-46-4 1-tert-Butyl 2-Methyl (R)-Aziridine-1,2-dicarboxylate 
• 154632-86-7 O₁-benzyl-O₂-methyl-(2R)-aziridine-1,2-dicarboxylate 

Relevant articles and documents

Method for catalyzing asymmetric Henry reaction of trifluoromethyl ketone

The invention provides a method for catalyzing asymmetric Henry reaction of trifluoromethyl ketone. The method adopts a brand-new catalyst namely a compound shown as a formula I, and is simple to operate, high in substrate universality, high in reaction y

LZC696 intermediate and synthetic method therefor

The invention discloses a compound which is (R)-tert-butyl(1,((1,1'biphenyl)-4-yl)3-((t-butyldimethylsilyl)oxo)propane-2-yl)carbamate, and the structural formula of the compound is as shown in formula A in the specification. An LZC696 intermediate is synthetized by adopting the compound, the whole technological process is free of expensive reagents or raw materials, free of sensitive reaction for oxygen and simple in purifying procedure, and commercial using purity can be achieved only by recrystallization purification of the compound 3 and the final product. The synthetic process of the invention is low in cost, simple and environmentally-friendly, and is suitable for industrial mass production.

Studies on the synthesis of orthogonally protected azalanthionines, and of routes towards β-methyl azalanthionines, by ring opening of N-activated aziridine-2-carboxylates

Orthogonally protected azalanthionines were successfully synthesised by the ring-opening of N-activated aziridine-2-carboxylates with protected diaminopropanoic acids (DAPs). The required DAPs were also prepared by ring-opening of N-activated aziridine-2-carboxylates with para-methoxybenzylamine, but it was found that the choice of aziridine protecting groups dictated both the success of the reaction as well as the regioselectivity of the isolated products. Attempts to extend the methodology to the preparation of the more sterically demanding β-methyl azalanthionines have, so far, been unsuccessful.