16047-86-2 Usage
Description
2,2-dimethyl-3-(methylamino)propan-1-ol, also known as N-methyl-2,2-dimethylamino-1-propanol, is an organic compound with the molecular formula C6H15NO. It is a colorless liquid at room temperature and is characterized by its amine functional group and two methyl groups attached to the second and third carbon atoms of the propane chain. 2,2-dimethyl-3-(methylamino)propan-1-ol is known for its reactivity and is commonly used as a building block in the synthesis of various pharmaceuticals and chemical compounds.
Uses
Used in Pharmaceutical Industry:
2,2-dimethyl-3-(methylamino)propan-1-ol is used as a chemical reagent for the preparation of azetidines, which are four-membered ring aza-analogues of cyclobutane. Azetidines are important structural motifs found in various natural products and pharmaceutical compounds, such as antibiotics and anticancer drugs. The use of 2,2-dimethyl-3-(methylamino)propan-1-ol in the synthesis of azetidines allows for the development of novel and potentially more effective therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,2-dimethyl-3-(methylamino)propan-1-ol serves as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and unique structural features make it a valuable component in the synthesis of various molecules, including those with potential applications in materials science, agrochemicals, and other specialty chemicals.
Used in Research and Development:
2,2-dimethyl-3-(methylamino)propan-1-ol is also utilized in research and development laboratories for the exploration of new synthetic routes and the development of innovative chemical processes. Its unique properties and reactivity make it an attractive candidate for the design and synthesis of novel compounds with potential applications in various industries.
Synthesis Reference(s)
The Journal of Organic Chemistry, 15, p. 873, 1950 DOI: 10.1021/jo01150a026
Check Digit Verification of cas no
The CAS Registry Mumber 16047-86-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,0,4 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16047-86:
(7*1)+(6*6)+(5*0)+(4*4)+(3*7)+(2*8)+(1*6)=102
102 % 10 = 2
So 16047-86-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H15NO/c1-6(2,5-8)4-7-3/h7-8H,4-5H2,1-3H3
16047-86-2Relevant articles and documents
Study of the Conformational Equilibria of 2-Z-3-Methyl-1,3,2-oxazaphosphorinanes. Steric and Stereoelectronic Influences on the Orientation of the Me2N Substituent on Three-Coordinate Phosphorus
Huang, Yande,Yu, Jaehoon,Bentrude, Wesley G.
, p. 4767 - 4773 (1995)
The conformations of a series of 1,3,2-oxazaphosphorinanes containing tree-coordinate phosphorus, 1-9, have been determined by the use of 1H, 31P, and 13C NMR spectroscopy.The rings were substituted at ring nitrogen, N(3), with a methyl group to compare its effect on conformational energies with those of 1,3,2-oxazaphosphorinanes reported earlier that featured a larger substituent at N(3), Ph or i-Pr.Quite expectedly, like those rings previously studied with Ph or i-Pr at N(3), a MeO or (CF3)2CHO substituent at phosphorus has a strong preference to be axial on a chair-form ring, 1-4, cis-7, and cis-8, or pseudoaxial on a ring in a twist/boat conformation, trans-7.However, when Me2N is attached to phosphorus, the newly studied N(3)Me rings display a chair-chair conformational equilibrium, 10 ->///- 11 is opposite to that found for four-coordinate phosphorus containing 1,3,2-oxazaphosphorinanes in which Me2NP(ax)/N(3)Ph repulsions that destabilize 10 appear to be dominant.
TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS
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, (2013/03/26)
There is provided compounds of formula (I), wherein R1, R2, X, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).
