1606-49-1 Usage
Description
1,4,5,6-Tetrahydropyrimidine (THP) is a cyclic amidine known for its ability to act as a carbon dioxide fixation agent. It reacts with carbon dioxide to form a zwitterionic adduct (THP-CO2), making it a versatile compound with potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
1,4,5,6-Tetrahydropyrimidine is used as a building block for the synthesis of various pharmaceutical agents, particularly derivatives that can act as neuromuscular blocking, cardiovascular, and antidepressant agents. These derivatives have the potential to improve the treatment of various medical conditions by targeting specific physiological pathways.
Used in Environmental Applications:
1,4,5,6-Tetrahydropyrimidine is used as a carbon dioxide fixation agent for its ability to react with CO2 and form a zwitterionic adduct. This property can be utilized in environmental applications, such as carbon capture and storage, to help mitigate the effects of climate change by reducing the amount of CO2 released into the atmosphere.
Used in Chemical Research:
1,4,5,6-Tetrahydropyrimidine serves as an important compound in chemical research, particularly in the development of new materials and compounds with specific properties. Its unique reactivity with carbon dioxide and its potential applications in various industries make it a valuable subject of study for chemists and material scientists.
Check Digit Verification of cas no
The CAS Registry Mumber 1606-49-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,0 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1606-49:
(6*1)+(5*6)+(4*0)+(3*6)+(2*4)+(1*9)=71
71 % 10 = 1
So 1606-49-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H8N2/c1-2-5-4-6-3-1/h4H,1-3H2,(H,5,6)
1606-49-1Relevant articles and documents
Fast equilibrium of zwitterionic adduct formation in reversible fixation-release system of CO2 by amidines under dry conditions
Aoyagi, Naoto,Furusho, Yoshio,Sei, Yoshihisa,Endo, Takeshi
, p. 5476 - 5480 (2013)
We investigated the fixation of CO2 by several amidines in solution and found that simple monocyclic amidines fixed CO2 under dry conditions to quantitatively afford the corresponding bicarbonates through hydrolysis of the zwitterion
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Ito et al.
, p. 4447,4448 (1973)
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Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?
Tanaka, Nao,Usuki, Toyonobu
, p. 5514 - 5522 (2020/07/24)
Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1–100 molpercent) with H2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 molpercent Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept?).
Selective hydrogenation of N-heterocyclic compounds using Ru nanocatalysts in ionic liquids
Konnerth, Hannelore,Prechtl, Martin H. G.
supporting information, p. 2762 - 2767 (2017/07/24)
N-Heterocyclic compounds have been tested in the selective hydrogenation catalysed by small 1-3 nm sized Ru nanoparticles (NPs) embedded in various imidazolium based ionic liquids (ILs). Particularly a diol-functionalised IL shows the best performance in the hydrogenation of quinoline to 1,2,3,4-tetrahydroquinoline (1THQ) with up to 99% selectivity.
