1607433-31-7Relevant articles and documents
Metal-free oxidative ipso-carboacylation of alkynes: Synthesis of 3-acylspiro[4,5]trienones from N-arylpropiolamides and aldehydes
Ouyang, Xuan-Hui,Song, Ren-Jie,Li, Yang,Liu, Bang,Li, Jin-Heng
, p. 4582 - 4589 (2014/06/09)
A general and metal-free radical route to synthesis of 3-acylspiro[4,5] trienones is established that utilizes TBHP (tert-butyl hydrogenperoxide) as an oxidation and a reaction partner to trigger the oxidative ipso-carboacylation of N-arylpropiolamides with aldehydes. This method offers a new difunctionalization of alkynes through oxidative cross coupling of the aldehyde C(sp2)-H bond with an ipso-aromatic carbon.