160938-51-2Relevant articles and documents
ELECTROCHEMICAL REDUCTION OF PRISTINAMYCIN IA AND RELATED STREPTOGRAMINS IN AQUEOUS ACIDIC MEDIUM
Largeron, M.,Vuilhorgne, M.,Potier, I. Le,Auzeil, N.,Bacque, E.,and al.
, p. 6307 - 6332 (2007/10/02)
The electrochemical reduction of the picolinoyl residue of pristinamycinIA and related streptogramins was performed at a mercury cathode, in aqueous medium.The presence of a peptidic lactone residue at the amide nitrogen atom markedly modified the expected cathodic behaviour of pyridyl carboxamides: in particular, we observed the reduction of the pyridyl ring into tetrahydropyridine derivatives.Thanks to a series of model heterocyclic carboxamides, increasing steric hindrance at the amide nitrogen position was shown to lead to enhanced reduction of the heterocyclic ring.