1609401-43-5

Basic information

• Product Name: 4-bromo-2,6-dimethyl-N-(quinolin-8-yl)benzamide
• Synonyms: 4-bromo-2,6-dimethyl-N-(quinolin-8-yl)benzamide
• CAS NO: 1609401-43-5
• Molecular Weight: 355.234
• Mol File: 1609401-43-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-bromo-2,6-dimethyl-N-(quinolin-8-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2,6-dimethyl-N-(quinolin-8-yl)benzamide(1609401-43-5)
• EPA Substance Registry System: 4-bromo-2,6-dimethyl-N-(quinolin-8-yl)benzamide(1609401-43-5)

Safety Data

• Hazardous Substances Data: 1609401-43-5(Hazardous Substances Data)

Upstream product

• 110-05-4 di-tert-butyl peroxide 
• 299928-52-2 4-bromo-N-quinolin-8-ylbenzamide 
• 80-48-8 methyl p-toluene sulfonate 
• 578-66-5 8-amino quinoline 
• 74346-19-3 4-bromo-2,6-dimethylbenzoic acid 

Relevant articles and documents

Nickel-Catalyzed Ortho C–H Methylation of Aromatic Amides with Di-tert-butyl Peroxide as Methylation Reagent

A new efficient protocol for the ortho-methylation of benzamides with DTBP has been developed via Ni(II)-catalyzed C–H activation directed by 8-aminoquinoline. This method is performed under base-free, ligand-free conditions and utilizes cheap and commercially available reagents. Moreover, the by-product acetone derived from DTBP does not affect the purification of the product.

Isoindolone synthesis via palladium-catalysed intramolecular amination of benzylic C-H bonds

A new method for the construction of isoindolones is presented in this paper. Four 7-methyl-2-(8-quinolinyl)-2,3-dihydro-1Hisoindol-1-ones were synthesised from 2,6-dimethyl -N-(8-quinolinyl)benzamides via intramolecular direct amination of benzylic C-H bonds. This approach provides a convenient method affording structurally new isoindolones for medicinal chemistry research.