1609691-97-5Relevant articles and documents
Asymmetric Total Synthesis of (-)- trans -Blechnic Acid via Rhodium(II)-Catalyzed C-H Insertion and Palladium(II)-Catalyzed C-H Olefination Reactions
Ito, Motoki,Namie, Ryosuke,Krishnamurthi, Janagiraman,Miyamae, Hitomi,Takeda, Koji,Nambu, Hisanori,Hashimoto, Shunichi
, p. 288 - 292 (2014/02/14)
An asymmetric total synthesis of (-)-trans-blechnic acid, a dihydrobenzofuran neolignan, has been achieved. The key steps involve an elaboration of the cis-2,3-dihydrobenzofuran core structure by enantio- and diastereoselective intramolecular C-H insertion using dirhodium(II) tetrakis[N-phthaloyl-(R)-tert-leucinate] [Rh2(R-PTTL)4] and a direct coupling of an acrylate unit with the core structure employing Yu's palladium(II)-catalyzed intermolecular C-H olefination. Georg Thieme Verlag Stuttgart, New York.