16098-04-7

Basic information

• Product Name: N-(4-methylphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)amine
• Synonyms: N-(4-methylphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)amine
• CAS NO: 16098-04-7
• Molecular Formula: C₁₆H₁₄N₂S
• Molecular Weight: 266.36076
• Mol File: 16098-04-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-methylphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)amine(16098-04-7)
• EPA Substance Registry System: N-(4-methylphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)amine(16098-04-7)

Safety Data

• Hazardous Substances Data: 16098-04-7(Hazardous Substances Data)

Upstream product

• 622-52-6 p-methylphenylthiourea 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 19433-17-1 acetophenone O-acetyloxime 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 43009-17-2 4-methylphenyl dithiocarbamic acid triethylammonium 
• 4098-17-3 1-(1-azido-2-iodoethyl)benzene 
• 106-49-0 p-toluidine 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 

Relevant articles and documents

Thiocyanation and 2-Amino-1,3-thiazole Formation in Water Using Recoverable and Reusable Glycosylated Resorcin[4]arene Cavitands

A family of three spatially directional resorcin[4]arene cavitand glycoconjugates (RCGs) have been applied as efficient recoverable and reusable inverse phase transfer catalysts for eco- A nd environmentally friendly thiocyanation and 2-amino-1,3-thiazole formation reactions in water. The results show that RCGs (1 mol %) were capable of hosting and catalyzing various water-insoluble bromo/thiocyanato substrates in water without the use of any co-organic solvents. The recoverability and reusability of RCG catalytic systems, that is, RCG1 and RCG3, were also examined upon a simple extraction of the desired products using DCM or ethyl acetate, followed by subjecting the recovered aqueous solution containing the RCG catalysts to the next reaction cycles.

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Copper-Catalyzed Coupling of Oxime Acetates with Isothiocyanates: A Strategy for 2-Aminothiazoles

A new strategy for 2-aminothiazoles is developed via the copper-catalyzed coupling of oxime acetates with isothiocyanates. Various 4-substituted and 4,5-disubstituted 2-aminothiazoles were formed smoothly under mild reaction conditions. This process involved copper-catalyzed N-O bond cleavage, activation of vinyl sp2 C-H bonds, and C-S/C-N bond formations. It is noteworthy that the oxime acetates were used not only as a substrate but also as a single oxidant.