16106-20-0

Basic information

• Product Name: ISOSORBIDE 2-MONONITRATE
• Synonyms: IS-2-MN;ISOSORBIDE 2-MONONITRATE;1,4:3,6-dianhydro-,2-nitrate,d-glucito;1,4:3,6-dianhydro-d-glucito2-nitrate;1,4:3,6-dianhydro-d-glucitol2-nitrate;1,4:3,6-dianhydrosorbitol2-mononitrate;2-ismn;isosorbide2-nitrate
• CAS NO: 16106-20-0
• Molecular Formula: C₆H₉NO₆
• Molecular Weight: 191.14
• EINECS: 240-271-4
• Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 16106-20-0.mol
• Article Data: 22

Chemical Properties

• Melting Point: >51.5°C
• Boiling Point: 326.86°C (rough estimate)
• Flash Point: 174.2°C
• Appearance: /
• Density: 1.5784 (rough estimate)
• Vapor Pressure: 8.66E-07mmHg at 25°C
• Refractive Index: 1.4860 (estimate)
• Storage Temp.: -20°C Freezer
• PKA: 13.09±0.40(Predicted)
• CAS DataBase Reference: ISOSORBIDE 2-MONONITRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOSORBIDE 2-MONONITRATE(16106-20-0)
• EPA Substance Registry System: ISOSORBIDE 2-MONONITRATE(16106-20-0)

Safety Data

• RTECS: LZ4385500
• Hazardous Substances Data: 16106-20-0(Hazardous Substances Data)

Usage

Description

Isosorbide 2-mononitrate, a metabolite of Isosorbide Dinitrate, is a white to ivory crystalline powder. It is primarily recognized for its vasodilatory properties, which contribute to its use in the medical field.

Uses

Used in Pharmaceutical Industry:
Isosorbide 2-mononitrate is used as an antianginal agent for the treatment of angina pectoris. It functions by causing vasodilation, which helps to increase blood flow and reduce the workload on the heart, thereby alleviating the symptoms of angina.
Used in Cardiovascular Applications:
In the field of cardiology, Isosorbide 2-mononitrate is utilized to manage and prevent angina attacks. Its vasodilatory action helps to improve blood flow to the heart muscle, reducing the frequency and severity of angina episodes.
Used in Chronic Stable Angina Treatment:
Isosorbide 2-mononitrate is used as a long-acting medication for the management of chronic stable angina. It is particularly effective in providing relief from chest pain and discomfort associated with physical exertion or emotional stress.
Used in Pulmonary Hypertension Therapy:
In some cases, Isosorbide 2-mononitrate may also be used to treat pulmonary hypertension, a condition characterized by high blood pressure in the arteries of the lungs. Its vasodilatory properties help to reduce the pressure and improve overall lung function.
Overall, Isosorbide 2-mononitrate is a versatile compound with a range of applications in the medical field, primarily focused on cardiovascular health and the treatment of angina pectoris.

InChI:InChI=1/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5-,6-/m1/s1

Upstream product

• 50-70-4 D-sorbitol 
• 39813-48-4 isosorbide 2-acetate-5-mononitrate 
• 87-33-2 isosorbide dinitrate 
• 84207-83-0 isosorbide 2-O-butanoate 
• 652-67-5 Isosorbide 
• 13042-39-2 isosorbide 2-acetate 
• 13042-38-1 [(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate 
• 7664-93-9 sulfuric acid 
• 79-31-2 isobutyric Acid 
• 56-23-5 tetrachloromethane 
• 75648-24-7 (3S,3aR,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl benzoate 
• 56389-86-7 (3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl benzoate 

Downstream Products

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• 1072106-00-3 isosorbide-2-(2-chlorophenylcarbamate)-5-mononitrate 
• 1072105-99-7 isosorbide-2-phenylcarbamate-5-mononitrate 
• 1072105-97-5 isosorbide-2-(cyclohexylcarbamate)-5-mononitrate 
• 1072106-01-4 isosorbide-2-(3,4-dichlorophenylcarbamate)-5-mononitrate 
• 876385-21-6 isosorbide-2-(benzylcarbamate)-5-mononitrate 
• 1072106-02-5 isosorbide-2-(3-chlorophenylcarbamate)-5-mononitrate 
• 1072105-98-6 isosorbide-2-(3-trifluoromethylphenylcarbamate)-5-mononitrate 
• 1196117-80-2 (3S,3aR,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl 2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate 
• 1609973-49-0 C₁₃H₁₂N₂O₁₀ 
• 1609973-56-9 C₂₇H₃₇N₃O₈S 
• 1609973-51-4 C₂₈H₃₇N₃O₁₁S 
• 1609973-52-5 C₂₈H₃₈N₂O₉S 
• 1609973-54-7 C₂₇H₃₆N₄O₁₀S 

Related news

Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites ISOSORBIDE 2-MONONITRATE (cas 16106-20-0) and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma07/16/2019

A specific liquid chromatography–tandem mass spectrometry (LC-ESI-MS/MS) assay was developed and validated for simultaneous determination of two active metabolites of isosorbide dinitrate (ISDN), namely, isosorbide 2-mononitrate (IS 2-MN) and isosorbide 5-mononitrate (IS 5-MN). A simple protein...detailed

Relevant articles and documents

Synthesis method and application of isosorbide mononitrate

The invention belongs to the field of medicine synthesis, and discloses a synthesis method and application of isosorbide mononitrate. The synthesis method of the isosorbide mononitrate provided by the invention adopts a one-pot method and comprises the following steps: adding sorbitol into concentrated sulfuric acid, dehydrating and cyclizing, adding nitrate, carrying out nitration reaction, and adding zinc powder to carry out reduction reaction, thereby obtaining the isosorbide mononitrate. The synthesis method has the advantages of simple process flow, high raw material utilization rate and production cost saving. The method is suitable for synthesizing the isosorbide mononitrate, and the obtained isosorbide mononitrate is used for preparing the isosorbide mononitrate for injection.

A 5 - isosorbide Mononitrate preparation method (by machine translation)

The present invention provides a 5 - isosorbide Mononitrate synthetic method. The method includes the steps of: in order to isosorbide as raw materials, with the nitrates TMSCl nitrating agent in three of the aluminum chloride under the action of selective nitration sorbitan 5 - hydroxyl, completion of the reaction, the reaction liquid is poured into ice water, adjusting the pH value to neutral, filtering precipitation, phase separation, the aqueous phase of the liquid organic solvent extraction, the organic phase into the drying agent and, decolorized with active carbon, concentrated under reduced pressure to dry, to obtain high-purity of 5 - isosorbide Mononitrate. The scheme of this invention mild reaction conditions, nitration high selectivity, after treatment is simple, high product yield and purity, is suitable for industrial production. (by machine translation)

Method for synthesizing 5-isosorbide mononitrate by aid of micro-channel reactors

The invention belongs to the field of medicine synthesis, and particularly discloses a method for synthesizing 5-isosorbide mononitrate by the aid of micro-channel reactors. The method includes pumping nitrification reagents and isosorbide liquid into the micro-channel reactors and carrying out hybrid reaction; allowing products to flow out from outlets of the micro-channel reactors after the reaction is completely carried out; carrying out after-treatment on the products and separating and purifying the products to obtain the 5-isosorbide mononitrate which is a target product. The method hasthe advantages that the method is short in reaction time and is safe as compared with the traditional processes, and the yield of the 5-isosorbide mononitrate can be greatly increased.