161125-88-8Relevant articles and documents
Ortho-Directed Metalation of 3-Heterosubstituted 4-Methyl-6-phenylpyridazines
Sitamze, Jean-Marie,Mann, Andre,Wermuth, Camille-Georges
, p. 271 - 276 (2007/10/02)
Side-chain metalation of 4-methyl-6-phenylpyridazines (2-4) with lithium diisopropylamide or 2,2,6,6-tetramethylpiperidide and subsequent alkylation with various electrophiles have been investigated.Depending on the substituent attached at the 3-position (Cl, OMe or NHCOtBu), the prepatration of the alkylated pyridazines was more or less efficient.