161468-31-1Relevant articles and documents
Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum
Buskes, Melissa J.,Harvey, Katherine L.,Prinz, Boris,Crabb, Brendan S.,Gilson, Paul R.,Wilson, David J.D.,Abbott, Belinda M.
, p. 2389 - 2396 (2016)
A series of isoquinolines have been evaluated in a homology model of Plasmodium falciparum Protein Kinase A (PfPKA) using molecular dynamics. Synthesis of these compounds was then undertaken to investigate their structure-activity relationships. One compo
Studies on the synthesis of benzimidazo [2,1- a]isoquinolines
Deady, Leslie W.,Loria, Paul M.,Rodemann, Thomas
, p. 941 - 945 (2007/10/03)
The reaction of the isocoumarin derivative 1-acetylimino-3-methyl-1H-2-benzopyran-4-carbonitrile (1a) with aromatic ortho diamines provides entry to the benzimidazo[2,1-a]isoquinoline and related systems. Various conversions of the methyl and cyano groups