16156-93-7

Basic information

• Product Name: 1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole
• Synonyms: 1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole
• CAS NO: 16156-93-7
• Molecular Formula: C8H12 Cl N3 O3
• Molecular Weight: 233.6522
• Mol File: 16156-93-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 79.0-79.5 °C(Solv: water (7732-18-5))
• Boiling Point: 416.8°Cat760mmHg
• Flash Point: 205.9°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 8.97E-07mmHg at 25°C
• Refractive Index: 1.569
• Solubility: Ethyl Acetate
• PKA: 2.55±0.34(Predicted)
• CAS DataBase Reference: 1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole(16156-93-7)
• EPA Substance Registry System: 1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole(16156-93-7)

Safety Data

• Hazardous Substances Data: 16156-93-7(Hazardous Substances Data)

Usage

Description

1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole is a chemical compound belonging to the imidazole class. It is characterized by its unique molecular structure, which features a 2-methyl group and a 5-nitro group attached to the imidazole ring. Additionally, it has a 2-chloroethoxyethyl substituent attached to the 1-position of the imidazole ring. 1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole is known for its potential biological activities and is related to the antiprotozoal agent Metronidazole.

Uses

1. Used in Pharmaceutical Industry:
1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole is used as an analogue and impurity of the antiprotozoal agent Metronidazole (M338880) for its potential antiprotozoal activity. It is particularly relevant in the development and improvement of treatments for various protozoal infections.
2. Used in Anthelmintic Applications:
1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole is used as a potential antitrichomonal agent, which means it can be employed in the treatment of trichomoniasis, a sexually transmitted parasitic infection caused by the protozoan Trichomonas vaginalis. The compound's activity is attributed to its structural similarity to other 1-substituted-2-methyl-5-nitroimidazoles that have demonstrated antitrichomonal properties.
3. Used in Research and Development:
1-[2-(2-Chloroethoxy)ethyl]-2-methyl-5-nitro-1H-imidazole can be utilized in research and development for the synthesis of new drugs and the study of their mechanisms of action. Its structural relationship to Metronidazole and other biologically active imidazoles makes it a valuable compound for exploring new therapeutic strategies against various diseases, particularly those caused by protozoan parasites.

InChI:InChI=1/C8H12ClN3O3/c1-7-10-6-8(12(13)14)11(7)3-5-15-4-2-9/h6H,2-5H2,1H3

Relevant articles and documents

1-substitution in 2-methyl-4(5)-nitroimidazole. I. Synthesis of compounds with potential antitrichomonal activity.

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