161596-37-8Relevant articles and documents
Candida antarctica lipase A - A powerful catalyst for the resolution of heteroaromatic β-amino esters
Solymar, Magdolna,Fueloep, Ferenc,Kanerva, Liisa T.
, p. 2383 - 2388 (2007/10/03)
Enantioselective acylations of 3-amino-3-heteroarylpropanoates (ArCH(NH2)CH2CO2Et; Ar=2- or 3-thienyl or -furyl) were performed in the presence of Candida antarctica lipase A. As a result of the excellent chemo- and enantioselectivities (E >100), gram-scale resolutions were carried out in ethyl butanoate. The hydrochloride salts of the unreacted R substrates and the butanamides of the reactive S enantiomers were thus prepared.
Electrogenerated chiral building blocks for diastereoselective amidoalkylation reactions
Brungs,Danielmeier,Jakobi,Nothhelfer,Stahl,Zietlow,Steckhan
, p. 575 - 590 (2007/10/03)
Three different electrochemical methods have been applied for the synthesis of chiral building blocks for diastereoselective amidoalkylation reactions. These are A. the direct anodic α-methoxylation of amides and carbamates; B. anodic methoxylative decarboxylation of α-amino acid derivatives (Hofer-Moest reaction) C. indirect NaCl mediated anodic α-methoxylation of α-amino acid derivatives. The application of these building blocks for the synthesis of enantiomerically pure α-amino acids, dichiral 1,2-amino alcohols and chiral 1,3-diamines is described.