16176-77-5

Basic information

• Product Name: 1H-Indole, 2-methyl-1-phenyl-
• CAS NO: 16176-77-5
• Molecular Formula: C15H13N
• Molecular Weight: 207.275
• Mol File: 16176-77-5.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-methyl-1-phenyl-(16176-77-5)
• EPA Substance Registry System: 1H-Indole, 2-methyl-1-phenyl-(16176-77-5)

Safety Data

• Hazardous Substances Data: 16176-77-5(Hazardous Substances Data)

Usage

Derivative of indole

A heterocyclic aromatic organic compound

Usage

Synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Pharmacological properties

Potential as an anti-cancer agent

Antifungal and antibacterial properties

Versatile and potentially useful in various fields of research and application

Upstream product

• 67-64-1 acetone 
• 530-50-7 1,1-Diphenylhydrazine 
• 78133-82-1 [2-(Acetyl-phenyl-amino)-benzyl]-triphenyl-phosphonium 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 62-53-3 aniline 
• 95-20-5 2-methyl-1H-indole 
• 780-69-8 triethoxyphenylsilane 
• 589-09-3 N-allyl-N-phenylamine 
• 583-53-9 2,3-dibromobenzene 
• 694-80-4 2-bromo-1-chlorobenzene 
• 95-50-1 1,2-dichloro-benzene 
• 66950-63-8 phenyl N,N-dimethylsulfamate 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 108-95-2 phenol 

Downstream Products

• 1370351-61-3 (S,Z)-methyl 4-(2-methyl-1-phenyl-1H-indol-3-yl)pent-2-enoate 
• 1264995-22-3 (-)-ethyl (R)-2-(2-methyl-1-phenyl-1H-indol-3-yl)hexanoate 
• 1264995-20-1 (-)-ethyl (R)-2-(2-methyl-1-phenyl-1H-indol-3-yl)propanoate 

Relevant articles and documents

Preparation method of N-arylindole under copper catalysis

The invention provides a preparation method of N-arylindole under copper catalysis. The preparation method comprises the following steps: S1, selecting a proper amount of a reaction reagent, a catalyst, a solvent and the like; S2, sequentially adding the

N -Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst

An effective and general aryl amination protocol has been developed using a magnetically recoverable Ni(0) based nanocatalyst. This new stable catalyst was prepared on Fe3O4@SiO2 modified by EDTA and investigated by FT-IR, EDX, TEM, XRD, DLS, FE-SEM, XPS, NMR, TGA, VSM, ICP and elemental analysis techniques. The reaction proceeded via carbon-oxygen bond cleavage of (hetero)aryl carbamates and sulfamates under simple and mild conditions without the use of any external ligands. This method demonstrated functional group tolerance in the N-arylation of various nitrogen-containing compounds as well as aliphatic amines, anilines, pyrroles, pyrazoles, imidazoles, indoles, and indazoles with good to excellent yields. Furthermore, the catalyst could be easily recovered by using an external magnetic field and directly reused at least six times without notable reduction in its activity. This journal is

L-Arginine as a base and ligand for the palladium-catalyzed C-C and C-N cross-coupling reactions in aqueous media

L-Arginine (2-amino-5-guanidinopentanoic acid) acts as a base and ligand in reaction medium, exhibits a very high activity and recyclability to palladium-catalyzed C-C and C-N cross-coupling reactions in aqueous media. The corresponding Suzuki products were obtained in good to excellent yields by using various aryl halides (I, Br, Cl). Also, the cross coupling reactions of arylboronic acids with various amines in aqueous medium proceed in good to excellent yield under same conditions. Furthermore, the catalyst could be easily separated from the reaction mixture and could be recycled several times without significant loss in its catalytic activity.