1618078-93-5Relevant articles and documents
Cell-permeable bicyclic peptide inhibitors against intracellular proteins
Lian, Wenlong,Jiang, Bisheng,Qian, Ziqing,Pei, Dehua
, p. 9830 - 9833 (2014)
Cyclic peptides have great potential as therapeutic agents and research tools but are generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize specific intracellular targets. Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prolyl cis-trans isomerase (Pin1) isomerase resulted in potent, selective, proteolytically stable, and biologically active inhibitors against the enzymes.