16205-84-8 Usage
Description
ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE is a clear colorless liquid that is utilized in the chemical industry for the synthesis of various compounds. It is characterized by its unique chemical structure, which features a trimethylsilyl group attached to a propiolate ester. This combination of functional groups provides ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE with specific reactivity and properties that make it a valuable intermediate in organic synthesis.
Uses
Used in Chemical Synthesis:
ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a versatile building block in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE is used as a key intermediate in the synthesis of pharmaceutical compounds. Its reactivity and functional groups enable the creation of novel drug candidates with potential therapeutic applications.
Used in Material Science:
ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE is also utilized in the development of new materials with specific properties. Its incorporation into polymers and other materials can lead to the creation of materials with enhanced characteristics, such as improved stability or reactivity.
Used in the Preparation of 4-Ethoxycarbonyl-3-(Trimethylsilyl)Furan:
ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE is specifically used as a starting material in the synthesis of 4-ethoxycarbonyl-3-(trimethylsilyl)furan, a compound with potential applications in various fields, including pharmaceuticals and material science. Its use in this preparation highlights its versatility and importance in organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 16205-84-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,0 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 16205-84:
(7*1)+(6*6)+(5*2)+(4*0)+(3*5)+(2*8)+(1*4)=88
88 % 10 = 8
So 16205-84-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H14O2Si/c1-5-10-8(9)6-7-11(2,3)4/h5H2,1-4H3
16205-84-8Relevant articles and documents
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Kraihanzel,C.S.,Losee,M.L.
, p. 1983 - 1986 (1968)
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A silicon saisai fungus amine synthesis method
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Paragraph 0035-0037, (2019/04/02)
The invention provides a synthetic method for silthiopham, which belongs to the technical field of organic synthesis. The objective of the invention is to overcome the problems of complicated synthesis process, a great number of byproducts and severe environmental pollution of conventional synthetic methods for silthiopham. The synthetic method provided by the invention comprises the following steps: (1) with trimethylsilylacetylene as a raw material, under the protection of inert gas, reacting trimethylsilylacetylene with methyl chloroformate under the action of organic base so as to obtain methyl (trimethylsilyl)propiolate; (2) reacting methyl (trimethylsilyl)propiolate with allyl amine in a solvent under the action of a catalyst so as to obtain N-allyl-3-(trimethylsilyl)propiolamide; and (3) subjecting N-allyl-3-(trimethylsilyl)propiolamide with 3-mercapto-2-butanone to a heating reflux reaction under the action of an alkali catalyst and carrying out dehydration so as to obtain the final product silthiopham. The method has the advantages of usage of cheap and easily available raw materials, simple route, high yield and no usage of reagents severely polluting the environment, e.g., t-butyl nitrous acid and thionyl chloride.
A convergent approach to (-)-callystatin a based on local symmetry
Candy, Mathieu,Tomas, Lo?c,Parat, Sabrina,Heran, Virginie,Bienaymé, Hugues,Pons, Jean-Marc,Bressy, Cyril
supporting information, p. 14267 - 14271 (2013/01/15)
The key is symmetry! A convergent synthetic approach of the highly cytotoxic natural product (-)-callystatin A was developed assembling three fragments through Julia-Kocienski olefination and Stille cross-coupling. The new strategy relies on a pivotal local symmetry of the target molecule. In this preliminary study, particular attention was devoted to facilitate the catalytic enantiocontrol of strategic stereogenic centers present in each of the fragments (see scheme). Copyright
