162648-46-6

Basic information

• Product Name: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID
• Synonyms: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID;1-PYRIMIDIN-4-YLMETHANAMINE
• CAS NO: 162648-46-6
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 162648-46-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 390.685 °C at 760 mmHg
• Flash Point: 190.08 °C
• Appearance: /
• Density: 1.196
• Vapor Pressure: 8.36E-07mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID(162648-46-6)
• EPA Substance Registry System: 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID(162648-46-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 162648-46-6(Hazardous Substances Data)

Usage

General Description

1-Methyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid is a chemical compound with potential pharmaceutical applications. It is a carboxylic acid derivative of tetrahydroquinoline, which is a heterocyclic compound containing a quinolone ring. 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID has been studied for its potential medicinal properties, including as an anti-inflammatory agent and a potential treatment for neurodegenerative diseases. Its structure and functional groups make it a promising candidate for further pharmaceutical research and development.

InChI:InChI=1/C11H13NO2/c1-12-6-2-3-8-7-9(11(13)14)4-5-10(8)12/h4-5,7H,2-3,6H2,1H3,(H,13,14)

Upstream product

• 74-88-4 methyl iodide 
• 5382-49-0 1,2,3,4-tetrahydroquinoline-6-carboxylic acid 
• 177478-49-8 methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate 
• 38896-30-9 6-(methoxycarbonyl)quinoline 
• 493-50-5 1-methyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde 

Downstream Products

• 845877-81-8 1-methyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid [2-hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-amide 

Relevant articles and documents

INHIBITORS OF ENL/AF9 YEATS

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Heterocyclic esters of rapamycin

A compound of the structure STR1 wherein R and R1 are each, independently, STR2 or hydrogen, R2 is a heterocyclic radical which may be optionally substituted; n=0-6; with the proviso that R and R1 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.