162662-27-3

Basic information

• Product Name: 4-(METHOXYMETHYL)PHENYLBORONIC ACID
• Synonyms: [4-(METHOXYMETHOXY)PHENYL]-BORONIC ACID;4-METHOXYMETHYLBENZENEBORONIC ACID;4-(METHOXYMETHYL)PHENYLBORONIC ACID;AKOS BRN-0213;4-(methxoymethoxy)phenylboronic acid
• CAS NO: 162662-27-3
• Molecular Formula: C₈H₁₁BO₄
• Molecular Weight: 181.98
• Product Categories: Boronic acids;Aryl;Organoborons
• Mol File: 162662-27-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 346.27 °C at 760 mmHg
• Flash Point: 163.218 °C
• Appearance: /
• Density: 1.19
• Vapor Pressure: 0.000657mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.62±0.16(Predicted)
• CAS DataBase Reference: 4-(METHOXYMETHYL)PHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(METHOXYMETHYL)PHENYLBORONIC ACID(162662-27-3)
• EPA Substance Registry System: 4-(METHOXYMETHYL)PHENYLBORONIC ACID(162662-27-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• Hazardous Substances Data: 162662-27-3(Hazardous Substances Data)

Usage

General Description

4-(Methoxymethyl)phenylboronic acid is a chemical compound with the molecular formula C8H11BO4. It is a boronic acid derivative and is commonly used as a building block in organic synthesis and medicinal chemistry. 4-(METHOXYMETHYL)PHENYLBORONIC ACID has been studied for its potential applications in the field of drug discovery and development, particularly as a reagent for the formation of carbon-carbon bonds in organic reactions. It has also been investigated for its role in the development of novel materials and as a key component in the synthesis of various pharmaceutical and agrochemical intermediates. The compound's unique chemical structure and reactivity make it a valuable tool for researchers in the field of organic chemistry.

InChI:InChI=1/C8H11BO3/c1-12-6-7-2-4-8(5-3-7)9(10)11/h2-5,10-11H,6H2,1H3

Upstream product

• 25458-45-1 p-methoxymethoxybromobenzene 
• 106-41-2 4-bromo-phenol 
• 98491-29-3 1-iodo-4-(methoxymethoxy)benzene 
• 121-43-7 Trimethyl borate 

Downstream Products

• 132113-71-4 1,4-Dimethoxy-2-(4-methoxymethoxy-phenyl)-naphthalene 
• 162662-28-4 11-(Dimethylamino)-2-<4'-<(methoxymethyl)oxy>benzoyl>-12-<<2'-(trimethylsilyl)ethoxy>methyl>-9H-imidazo<4',5':3,4>pyrido<2,3-b>indole 
• 402490-66-8 1-[(Z)-2-Fluoro-2-(4-methoxymethoxy-phenyl)-vinyl]-3,5-dimethoxy-benzene 
• 402490-67-9 1-[(Z)-2-Fluoro-2-(4-methoxymethoxy-phenyl)-vinyl]-3,5-bis-methoxymethoxy-benzene 
• 884320-53-0 tert-butyl 2-[3-iodo-4-(4'-methoxymethoxyphenoxy)phenyl]-[1,1,2,2,-2H₄]ethylcarbamate 
• 884320-55-2 methyl 2-[3-iodo-4-(4'-methoxymethoxyphenoxy)phenyl]acetate 
• 884320-56-3 2-[3-iodo-4-(4'-methoxymethoxyphenoxy)phenyl]acetaldehyde 
• 92796-03-7 (4-hydroxyphenyl)naphthalene-1,4-dione 
• 132113-72-5 2-(4-Methoxymethoxy-phenyl)-[1,4]naphthoquinone 
• 132113-78-1 2-Aziridin-1-yl-3-(4-hydroxy-phenyl)-[1,4]naphthoquinone 
• 132113-73-6 2-Bromo-3-(3,5-dibromo-4-hydroxy-phenyl)-[1,4]naphthoquinone 
• 132113-74-7 2-Bromo-3-(3,5-dibromo-4-methoxymethoxy-phenyl)-[1,4]naphthoquinone 
• 132113-76-9 Methanesulfonic acid 2-[3-(3,5-dibromo-4-hydroxy-phenyl)-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino]-ethyl ester 
• 132113-75-8 Methanesulfonic acid 2-[3-(3,5-dibromo-4-methoxymethoxy-phenyl)-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino]-ethyl ester 

Relevant articles and documents

POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

To provide a polymerizable compound having a high polymerizability, a high conversion ratio and a high solubility in a liquid crystal composition, a polymerizable composition containing the compound, a liquid crystal composite prepared from the compositio

Trace amine-associated receptor agonists: Synthesis and evaluation of thyronamines and related analogues

We have previously shown that several thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormone, potently activate an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale [Scanlan, T. S.; Suchland, K. L.; Hart, M. E.; Chiellini, G.; Huang, Y.; Kruzich, P. J.; Frascarelli, S.; Crossley, D. A.; Bunzow, J. R.; Ronca-Testoni, S.; Lin, E. T.; Hatton, D.; Zucchi, R.; Grandy, D. K. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6), 638-642]. Herein, we report the synthesis of these thyronamines. Additionally, a large number of thyroamine derivatives were synthesized in an effort to understand the molecular basis of TAAR1 activation and hypothermia induction. Several derivatives were found to potently activate both rTAAR1 and mTAAR1 in vitro (compounds 77, 85, 91, and 92). When administered to mice at a 50 mg/kg dose, these derivatives all induced significant hypothermia within 60 min and exhibited a hypothermic induction profile analogous to 3-iodothyronamine (1, T1AM) except 91, which proved to be more efficacious. On the basis of this result, a dose-dependent profile for 91 was generated and an ED50 of 30 μmol/kg was calculated. Compound 91 proved to be more potent than T1AM for TAAR1 activation and exhibits increased potency and efficacy for hypothermia induction. These data further strengthen the pharmacological correlation linking TAAR1 activation by thyronamines and hypothermia induction in mice.

Vitamin D analogues

The present invention relates to novel triaromatic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, in car