162787-61-3

Basic information

• Product Name: 2-METHANESULFONYLAMINO-BENZOIC ACID
• Synonyms: 2-METHANESULFONYLAMINO-BENZOIC ACID;2-[(METHYLSULFONYL)AMINO]BENZOIC ACID;2-(Methanesulfonylamino)benzoic acid, min. 95 %;2-(Methylsulfonamido)benzoic acid;2-MethanesulfonaMidobenzoic acid;2-[(Methylsulphonyl)amino]benzoicacid97%
• CAS NO: 162787-61-3
• Molecular Formula: C₈H₉NO₄S
• Molecular Weight: 215.23
• Mol File: 162787-61-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 187-189 °C
• Boiling Point: 397.6°C at 760 mmHg
• Flash Point: 194.3°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 4.9E-07mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C
• PKA: 3.17±0.36(Predicted)
• CAS DataBase Reference: 2-METHANESULFONYLAMINO-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHANESULFONYLAMINO-BENZOIC ACID(162787-61-3)
• EPA Substance Registry System: 2-METHANESULFONYLAMINO-BENZOIC ACID(162787-61-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 162787-61-3(Hazardous Substances Data)

Usage

General Description

2-Methanesulfonylamino-benzoic acid, also known as mesalamine, is a chemical compound used as a medication to treat inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. It works by reducing inflammation in the digestive tract and is believed to be effective in preventing the relapse of these conditions. The compound is classified as an aminosalicylate drug and functions as a local anti-inflammatory agent in the colon. It is generally well-tolerated by most patients, with common side effects including headache, nausea, and abdominal pain. 2-Methanesulfonylamino-benzoic acid is available in various forms including oral tablets, capsules, and rectal suppositories. It is important to consult with a healthcare professional before using this medication, as it may interact with other drugs and have potential risks for certain individuals.

InChI:InChI=1/C8H9NO4S/c1-14(12,13)9-7-5-3-2-4-6(7)8(10)11/h2-5,9H,1H3,(H,10,11)

Upstream product

• 118-92-3 anthranilic acid 
• 124-63-0 methanesulfonyl chloride 
• 91013-48-8 2-methanesulfonylaminobenzoic acid ethyl ester 
• 716-41-6 methyl N-mesylanthranilate 
• 134-20-3 2-carbomethoxyaniline 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 87-25-2 2-ethoxycarbonylaniline 

Downstream Products

• 14107-94-9 o-Methansulfonamido-benzoesaeure-p-nitrophenylester 
• 934421-03-1 N-(butylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-2-methanesulfonylamino-benzamide 
• 934421-00-8 N-[benzylcarbamoyl-(3-bromo-phenyl)-methyl]-N-(2-hydroxy-ethyl)-2-methanesulfonylamino-benzamide 
• 934421-09-7 {2-cyclohexyl-2-[(2-hydroxy-ethyl)-(2-methanesulfonylamino-benzoyl)-amino]-acetylamino}-acetic acid tert-butyl ester 
• 934421-05-3 N-(cyclohexylcarbamoyl-furan-2-yl-methyl)-N-(2-hydroxy-ethyl)-2-methanesulfonylamino-benzamide 
• 1025713-51-2 1-(2-methanesulfonylamino-benzoyl)-piperidine-3-carboxylic acid ethyl ester 
• 1031357-47-7 C₂₅H₃₃N₃O₅S 
• 1029683-77-9 C₂₅H₃₃N₃O₅S 
• 1008103-33-0 C₂₅H₃₃N₃O₅S 
• 1008103-72-7 C₂₅H₃₃N₃O₅S 
• 1031359-08-6 C₃₁H₃₇N₃O₅S 
• 1029684-15-8 C₃₁H₃₇N₃O₅S 
• 1094024-97-1 C₁₀H₁₅N₃O₃S 
• 1220341-81-0 N-(2-(4-(6-(3-cyanophenyl)isoquinolin-8-ylamino)piperidine-1-carbonyl)phenyl)methanesulfonamide 

Relevant articles and documents

2-Aminophenyl-1H-pyrazole as a Removable Directing Group for Copper-Mediated C-H Amidation and Sulfonamidation

2-Aminophenyl-1H-pyrazole was discovered as a removable bidentate directing group for copper-mediated aerobic oxidative C(sp2-H) bond amidation and sulfonamidation. When Cu(OAc)2 was employed as the copper source and 1,1,3,3-tetramet

The effect of hydrogen bond on Br?nsted acid-catalyzed intramolecular hydroamination of unfunctionalized olefins

The catalytic activity of benzoic acid could be increased by introducing a hydrogen bond donor group at the ortho-position. Preliminary DFT calculation indicated that the activation of CC double bond was realized by the action of both the carboxyl group and the hydrogen bond donor. The amino group was brought to the activated CC bond by the interaction between the carboxyl oxygen and amino proton. This interaction also increased the nucleophilicity of the amino group. Thus, in the presence of 20 mol % of 2-(trifluoromethanesulfonamido)benzoic acid, intramolecular hydroamination of unfunctionalized olefins gave the corresponding products in up to 95% isolated yields.

TRIAZINE-BASED COMPOUND AND ULTRAVIOLET ABSORBER

A compound represented by the following formula (1): wherein each of R1b, R1c, R1d, R1g, R1h, R1i, R1k, R1m, R1n and R1p independently represents a hydrogen atom or a monovalent substituent, the monovalent substituents may combine with each other to form a ring, provided that at least one of R1c and R1h represents a hydrogen atom or a substituent having a positive σp value of the Hammett's rule, each of R1a, R1e, R1f and R1j independently represents a hydrogen atom or a monovalent substituent excluding —NHY1 and —OH, Y1 represents —COR1q or —SO2R1r, and each of R1q and R1r independently represents a monovalent substituent.