162818-40-8Relevant articles and documents
Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
Weldon, David J.,Shah, Falgun,Chittiboyina, Amar G.,Sheri, Anjaneyulu,Chada, Raji Reddy,Gut, Jiri,Rosenthal, Philip J.,Shivakumar, Develeena,Sherman, Woody,Desai, Prashant,Jung, Jae-Chul,Avery, Mitchell A.
, p. 1274 - 1279 (2014/03/21)
A new series of peptidomimetic pseudo-prolyl-homophenylalanylketones were designed, synthesized and evaluated for inhibition of the Plasmodium falciparum cysteine proteases falcipain-2 (FP-2) and falcipain-3 (FP-3). In addition, the parasite killing activ
An efficient synthesis of cyclic urethanes from Boc-protected amino acids through a metal triflate-catalyzed intramolecular diazocarbonyl insertion reaction
Jung, Jae-Chul,Avery, Mitchell A.
, p. 7969 - 7972 (2007/10/03)
A simple and efficient synthesis of cyclic urethanes and related oxazinanones 1a-l from diazoketones 3a-l is described. The transformation involves generation of carbenes by activation of diazo groups using metal triflates in intramolecular diazocarbonyl insertion reactions in high overall yields.
(S)-β3-homolysine- and (S)-β3-homoserine-containing β-peptides: CD spectra in aqueous solution
Abele, Stefan,Guichard, Gilles,Seebach, Dieter
, p. 2141 - 2156 (2007/10/03)
For further structural studies and for physiological investigations of β-peptides, it is necessary to have H2O-soluble derivatives. Thus, we have prepared β-hexa-, β-hepta-, and β-nonapeptides (1-6) with two, three, and seven side chains of lys
