1632-49-1 Usage
Derivative of pyrrole
A five-membered aromatic ring with a nitrogen atom The compound is based on a pyrrole structure, which consists of a five-membered ring with one nitrogen atom, providing the basis for its aromatic and chelating properties.
Two carboxylic acid groups
Potential chelating agent The presence of two carboxylic acid groups in the molecule allows it to form coordination compounds with metal ions, making it a potential chelating agent.
Diphenyl groups
Stability and hydrophobic properties The addition of two phenyl groups to the pyrrole ring provides stability to the molecule and introduces hydrophobic properties, which can be useful in various applications.
Applications in materials science
The compound's unique structure and properties make it valuable for research and development in materials science, potentially leading to new materials with specialized functions.
Organic synthesis
1H-Pyrrole-2,5-dicarboxylic acid, 3,4-diphenylcan be used as a building block or intermediate in the synthesis of more complex organic molecules, contributing to the development of new compounds and chemical reactions.
Pharmaceutical research
The chelating properties and stability of the compound make it a potential candidate for use in pharmaceutical applications, such as the development of new drugs or drug delivery systems.
Various chemical and industrial purposes
The compound's unique structure and properties can be applied in a wide range of chemical and industrial processes, making it a valuable addition to the field.
Check Digit Verification of cas no
The CAS Registry Mumber 1632-49-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,3 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1632-49:
(6*1)+(5*6)+(4*3)+(3*2)+(2*4)+(1*9)=71
71 % 10 = 1
So 1632-49-1 is a valid CAS Registry Number.
1632-49-1Relevant articles and documents
Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors
Li, Guangzhe,Dong, Huijuan,Ma, Yao,Shao, Kun,Li, Yueqing,Wu, Xiaodan,Wang, Shisheng,Shao,Zhao, Weijie
supporting information, p. 2327 - 2331 (2019/07/09)
The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, respectively. The results showed that neolamellarin A 1 (IC50 = 10.8 ± 1.0 μM) and derivative 2b (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biological activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small molecule probes for target protein identification.
Synthesis of 1',2',3',4',5'-pentamethyl-3,4-diphenylazaferrocene and its enantioselective C-2 functionalization via (-)-sparteine-mediated lithiation
Fukuda, Tsutomu,Koga, Yasuyuki,Iwao, Masatomo
experimental part, p. 1237 - 1248 (2009/06/28)
Lithiation of 1',2',3',4',5'-pentamethyl-3,4-diphenylazaferrocene (9) with sec-BuLi/(-)-sparteine (2) in Et2O at -78 °C followed by quenching with electrophiles gave the C-2 functionalized azaferrocenes (17) in good enantioselectivities (up to
