1634-63-5

Basic information

• Product Name: 1-(4-isopropyl-3-nitrophenyl)ethan-1-one
• Synonyms: 1-(4-isopropyl-3-nitrophenyl)ethan-1-one
• CAS NO: 1634-63-5
• Molecular Weight: 207.229
• Mol File: 1634-63-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-isopropyl-3-nitrophenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-isopropyl-3-nitrophenyl)ethan-1-one(1634-63-5)
• EPA Substance Registry System: 1-(4-isopropyl-3-nitrophenyl)ethan-1-one(1634-63-5)

Safety Data

• Hazardous Substances Data: 1634-63-5(Hazardous Substances Data)

Upstream product

• 98-82-8 Isopropylbenzene 
• 645-13-6 4-isopropylacetophenone 

Downstream Products

• 1634-42-0 (+/-)-3-<5-Aethyl-2-isopropyl-phenoxy>-butan-2-on 
• 1632-58-2 5-ethyl-2-isopropylphenol 
• 174482-81-6 4-isopropyl-3-nitrobenzoic acid 
• 855197-90-9 4-(α-hydroxy-isopropyl)-3-nitro-benzoic acid 
• 1634-62-4 1-(3-Hydroxy-4-isopropyl-phenyl)-ethan-1-on 
• 38262-72-5 3-(4-Isopropyl-3-nitro-benzoyl)-acrylsaeure 

Relevant articles and documents

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.