16346-60-4

Basic information

• Product Name: Acetamide, 2,2-dichloro-N-(4-nitrophenyl)-
• CAS NO: 16346-60-4
• Molecular Formula: C8H6Cl2N2O3
• Molecular Weight: 249.053
• Mol File: 16346-60-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2-dichloro-N-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2-dichloro-N-(4-nitrophenyl)-(16346-60-4)
• EPA Substance Registry System: Acetamide, 2,2-dichloro-N-(4-nitrophenyl)-(16346-60-4)

Safety Data

• Hazardous Substances Data: 16346-60-4(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 7664-93-9 sulfuric acid 
• 2563-99-7 N-phenyl-2,2-dichloroacetamide 
• 7697-37-2 nitric acid 
• 79-43-6 dichloro-acetic acid 
• 100-01-6 4-nitro-aniline 

Relevant articles and documents

Ozone-mediated Reaction of Anilides and Phenyl Esters with Nitrogen Dioxide: Enhanced Ortho-reactivity and Mechanistic Implications

In the presence of ozone, anilides 1 can be nitrated rapidly with nitrogen dioxide in chloroform at 0 deg C to give a high proportion of ortho-nitro derivatives (ortho:para = 1.2-4.4) in good yields.The phenyl esters 15 can be similarly nitrated on the aromatic ring without significant cleavage of the ester bond, giving a mixture of isomeric nitro derivatives in which the ortho-isomer predominantes (ortho:para = 1.1-1.5).The oridin of the enhanced ortho reactivity is discussed in terms of an electron-transfer process involving the nitrogen trioxide as initial electrophile.