1634687-04-9Relevant articles and documents
Catalyst-free, solvent-promoted and scalable multicomponent synthesis of 3-aminoalkylated indoles via a mannich-type reaction
Cao, Jian-Fei,Chen, Yan-Li,Guan, Zhi,He, Yan-Hong
, p. 721 - 727 (2014/07/07)
A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.