16352-77-5

Basic information

• Product Name: 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one
• Synonyms: 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one
• CAS NO: 16352-77-5
• Molecular Weight: 306.364
• Mol File: 16352-77-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one(16352-77-5)
• EPA Substance Registry System: 4-(4-dimethylamino benzylidene)-2-p-tolyloxazol-5(4H)-one(16352-77-5)

Safety Data

• Hazardous Substances Data: 16352-77-5(Hazardous Substances Data)

Upstream product

• 27115-50-0 N-(4-methylbenzoyl)glycine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 

Relevant articles and documents

5(4H)-Oxazolones as Novel Antitubercular Agents: Synthesis, Characterisation and Structure Activity Study

In search of novel anti tubercular agents, a series of twelve 4-(substituted benzylidene)-2-p-tolyloxazol-5(4H)-ones (5a-5l) has been synthesized, characterised and subjected to evaluate their antitubercular activity for the first time against Mycobacterium tuberculosis H37Rv (ATCC 27294). The out-put of these studies disclosed that all the synthesized target molecules of the series displayed good to moderate activity with MIC values ranging 2-32 μg/mL in comparison with the standard first line antitubercular drugs Rifampicin and Isoniazid. Compound 5e with three methoxy groups meta to each other, is the most distinctive compound identified amongst the series, because of its remarkable in vitro antitubercular activity and thus may act as a promising lead molecule for further explorations.