163595-81-1

Basic information

• Product Name: 5-benzyloxy-2-bromo-4,β-dimethoxystyrene
• Synonyms: 5-benzyloxy-2-bromo-4,β-dimethoxystyrene
• CAS NO: 163595-81-1
• Molecular Weight: 349.224
• Mol File: 163595-81-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-benzyloxy-2-bromo-4,β-dimethoxystyrene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyloxy-2-bromo-4,β-dimethoxystyrene(163595-81-1)
• EPA Substance Registry System: 5-benzyloxy-2-bromo-4,β-dimethoxystyrene(163595-81-1)

Safety Data

• Hazardous Substances Data: 163595-81-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 2973-59-3 2-bromoisovanillin 
• 6451-86-1 5-benzyloxy-2-bromo-4-methoxybenzaldehyde 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 

Downstream Products

• 221876-38-6 (5-benzyloxy-2-bromo-4-methoxyphenyl)acetaldehyde 
• 1432493-94-1 (E)-ethyl 4-(5-(benzyloxy)-2-bromo-4-methoxyphenyl)but-2-enoate 
• 1432494-02-4 ethyl 1-amino-6-(benzyloxy)-7-methoxynaphthalene-2-carboxylate 
• 128534-40-7 methyl 2-azido-3-(4-benzyloxy-2-(2,2-dimethoxyethyl)-5-methoxyphenyl)propenoate 
• 128534-41-8 methyl 6-benzyloxy-4-(2,2-dimethoxyethyl)-7-methoxyindole-2-carboxylate 
• 55323-56-3 2-(5-benzyloxy-2-bromo-4-methoxyphenyl)ethanol 
• 128534-33-8 4-benzyloxy-5-methoxy-2-(2-methoxyethenyl)benzaldehyde 
• 128534-39-4 (5-benzyloxy-2-bromo-4-methoxyphenyl)acetaldehyde dimethyl acetal 

Relevant articles and documents

Preparation method of aporphine alkaloid

The invention discloses a preparation method of aporphine alkaloid as shown in a formula III. The method comprises the following steps: taking a benzaldehyde compound as shown in a formula III-0 as a raw material, and sequentially carrying out Wittig reaction, Pictet-Spengler reaction, Heck reaction and palladium carbon hydrogen deprotection. A bromine-containing benzaldehyde derivative is selected as a raw material, the carbon-carbon coupling co-production rate and the reaction rate are increased through bromine atoms, and the reaction activity is improved; benzyl chloroformate is adopted for NH protection, and an electron withdrawing group is introduced, so that the reaction yield can be improved; and a styrene methyl ether derivative directly reacts with an acylated phenylethylamine derivative in an acid catalysis system by adopting a one-pot method so as to obtain benzyl tetrahydroisoquinoline. The preparation method has the advantages of mild reaction conditions, low toxicity of used reagents, easily available raw materials, convenient post-treatment and simpler reaction route compared with previous reports, and can be suitable for various reaction substrates.