163704-47-0

Basic information

• Product Name: 2,6-Diisopropyliodobenzene
• Synonyms: 2-Iodo-1,3-diisopropylbenzene;2-iodo-1,3-di(propan-2-yl)benzene;2,6-Diisopropyliodobenzene
• CAS NO: 163704-47-0
• Molecular Formula: C₁₂H₁₇I
• Molecular Weight: 288.16785
• Mol File: 163704-47-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2,6-Diisopropyliodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Diisopropyliodobenzene(163704-47-0)
• EPA Substance Registry System: 2,6-Diisopropyliodobenzene(163704-47-0)

Safety Data

• Hazardous Substances Data: 163704-47-0(Hazardous Substances Data)

Usage

General Description

2,6-Diisopropyliodobenzene is a chemical compound with the molecular formula C12H17I. It is a colorless to pale yellow liquid with a strong odor. It is primarily used as an intermediate in the synthesis of other organic compounds, particularly in the production of pharmaceuticals, pesticides, and dyes. 2,6-Diisopropyliodobenzene is also used as a reagent in organic chemistry reactions, such as in the preparation of various aryl iodides and other functionalized aromatic compounds. It is important to handle this chemical with care as it is toxic if ingested, inhaled, or absorbed through the skin, and can cause irritation to the eyes, skin, and respiratory system.

Upstream product

• 24544-04-5 2,6-diisopropylbenzenamine 
• 13922-41-3 1-Naphthylboronic acid 
• 82113-65-3 bis(trifluoromethanesulfonyl)amide 

Downstream Products

• 92035-95-5 2,6-bis-(1-methylethyl)benzoic acid 
• 25364-47-0 1-(2,6-diisopropylphenyl)-1H-imidazole 
• 85374-63-6 2,6-diisopropylbenzoyl chloride 
• 2078-54-8 2,6-diisopropylphenol 
• 854271-12-8 1,3-diisopropyl-2-(phenylethynyl)benzene 
• 156023-27-7 (2,6-diisopropylphenyl)acetylene 
• 1443747-04-3 1,4-di(2,6-diisopropylphenyl)-3-methyl-H-1,2,3-triazolium iodide 
• 1263862-50-5 1,4-bis(2,6-diisopropylphenyl)-1H-[1,2,3]-triazole 
• 1035347-44-4 2,6-diisopropylphenyl tert-butyldimethylsilyl ether 
• 863677-59-2 N-(2,6-diisopropyl)phenyl-N-(2-pyridyl)amine 

Relevant articles and documents

Arene diazonium saccharin intermediates: A greener and cost-effective alternative method for the preparation of aryl iodide

In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates, and (d) avoid the generation of heavy metal or corrosive waste.

A facile and sustainable protocol to the preparation of aryl iodides using stable arenediazonium bis(trifluoromethylsulfonyl)imide salts via the telescopic process

The preparation of aryl iodides in a telescopic reaction using tert-butyl nitrite as a diazotization reagent and a mixture of bis(trifluoromethane) sulfonamide and glacial acetic acid as a mild acidic agent in ethanol followed by iododediazoniation with tetraethylammonium iodide in water was investigated. The current method has other advantages such as minimized waste by avoiding solvent for the purification of products in diazotization step, simple experimental procedure, and good yield of the sterically hindered aryl amines, metal and strong acid-free waste and environmentally benign conditions. The noteworthy features of this study are the preparation of stable arenediazonium bis(trifluoromethylsulfonyl)imide salts that can be used with no significant loss activity after 1?week and bis(trifluoromethane)sulfonamide was recovered in high yields from reactions.

Cu-catalyzed fluorination of diaryliodonium salts with KF

A mild Cu-catalyzed nucleophilic fluorination of unsymmetrical diaryliodonium salts with KF is described. This protocol preferentially fluorinates the smaller aromatic ligand on iodine(III). The reaction exhibits a broad substrate scope and proceeds with high chemoselectivity and functional group tolerance. DFT calculations implicate a CuI/CuIII catalytic cycle.