1637568-94-5

Basic information

• Product Name: C₁₉H₁₈O₇
• Synonyms: C₁₉H₁₈O₇
• CAS NO: 1637568-94-5
• Molecular Weight: 358.348
• Mol File: 1637568-94-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₈O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₈O₇(1637568-94-5)
• EPA Substance Registry System: C₁₉H₁₈O₇(1637568-94-5)

Safety Data

• Hazardous Substances Data: 1637568-94-5(Hazardous Substances Data)

Upstream product

• 642-71-7 3,4,5-trimethoxyphenol 
• 859505-72-9 C₁₀H₇ClO₃ 
• 19675-63-9 4-(2-carboxyvinyl)benzoic acid 

Downstream Products

• 859505-61-6 C₁₉H₁₆O₇ 
• 859505-69-4 C₁₆H₁₀O₇ 

Relevant articles and documents

Synthesis and anti-influenza activities of novel baicalein analogs

A series of novel flavones derivatives were synthesized based on modification of the active ingredients of a traditional Chinese medicine Scutellaria baicalensis GEORGI and screened for anti-influenza activity. The synthetic baicalein (flavone) analogs, especially with the B-rings substituted with bromine atoms, were much more potent than oseltamivir or ribavirin against H1N1 Tamiflu-resistant (H1N1 TR) virus and usually with more favorable selectivity. The most promising were 5b, 5c, 6b and 6c, all displaying an 50% effective concentration (EC50) at around 4.0-4.5 μM, and a selective index (SI=50% cytotoxic concentration (CC50)/EC 50)>70. For seasonal H3N2-infected influenza virus, both 5a and 5b with SI >17.3 indicated superior to ribavirin. The flavonoids having both not-naturally-occurring bromo-substituted B-rings and appropriate hydroxyls positioning on the A-rings might be critical in determining the activity and selectivity against H1N1-Tamiflu-resistant infected influenza viruses.