163913-87-9

Basic information

• Product Name: myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse
• Synonyms: Deoxyribonucleic acid (human 35-55-myelin-oligodendroglial glycoprotein MOG-specifying);DNA (human 35-55-myelin-oligodendroglial glycoprotein MOG-specifying cDNA);DNA (human 35-55-myelin-oligodendroglial glycoprotein MOG-specifying);Myelin oligodendrocyte glycoprotein mouse rat 35-55;MOG 35-55 amide
• CAS NO: 163913-87-9
• Molecular Formula: C118H177N35O29S
• Molecular Weight: 2581.98
• Mol File: 163913-87-9.mol
• Article Data: 0

Chemical Properties

• Appearance: White to off-white powder
• Storage Temp.: −20°C
• CAS DataBase Reference: myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse(CAS DataBase Reference)
• NIST Chemistry Reference: myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse(163913-87-9)
• EPA Substance Registry System: myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse(163913-87-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 163913-87-9(Hazardous Substances Data)

Usage

Description

Myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse is a specific peptide fragment derived from the myelin oligodendrocyte glycoprotein (MOG), which is a component of the central nervous system. This peptide fragment is particularly relevant in the context of autoimmune diseases, such as multiple sclerosis, and is commonly used to generate an autoimmune animal model for research purposes. It is expressed in the hippocampus of rats and mice, making it a valuable tool for studying the pathogenesis and potential treatments for neurological disorders.

Uses

Used in Pharmaceutical Research:
Myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse is used as a research tool for the development of therapeutic strategies targeting autoimmune diseases, particularly multiple sclerosis. The peptide fragment helps researchers understand the immune response and the role of MOG in the disease process.
Used in Drug Delivery Systems:
In the field of drug delivery, myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse can be used as a targeting molecule for the development of novel drug delivery systems. By incorporating this peptide fragment into the design of drug carriers, researchers can potentially enhance the specificity and efficacy of therapeutic agents in treating neurological disorders.
Used in Diagnostic Applications:
This peptide fragment can also be employed in the development of diagnostic tools for detecting and monitoring the progression of autoimmune diseases, such as multiple sclerosis. By using the peptide fragment as a biomarker, researchers can gain insights into the disease's pathogenesis and identify potential therapeutic targets.
Used in Neurological Research:
Myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse is used as a research tool in the field of neuroscience to study the structure and function of the central nervous system, particularly in the context of myelin and oligodendrocyte biology. This peptide fragment can help researchers understand the mechanisms underlying demyelinating diseases and develop potential therapeutic interventions.
Used in Immunological Research:
In the field of immunology, myelin oligodendrocyte glycoprotein peptide fragment 35-55 rat, mouse is used to investigate the immune system's response to central nervous system components. This peptide fragment can be employed to study the role of autoimmunity in the development of neurological disorders and to develop strategies for modulating immune responses.
Used in Biomarker Discovery:
This peptide fragment can be utilized in the search for biomarkers associated with neurological disorders, particularly those involving myelin and oligodendrocyte dysfunction. By identifying and characterizing biomarkers, researchers can develop more accurate diagnostic tools and personalized treatment approaches for patients with these conditions.

Biochem/physiol Actions

Induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.