163981-88-2

Basic information

• Product Name: 1-Piperazinepropanamine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-
• CAS NO: 163981-88-2
• Molecular Formula: C18H31N3O2
• Molecular Weight: 321.463
• Mol File: 163981-88-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperazinepropanamine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinepropanamine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-(163981-88-2)
• EPA Substance Registry System: 1-Piperazinepropanamine, N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-(163981-88-2)

Safety Data

• Hazardous Substances Data: 163981-88-2(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivatives

Structural characteristics

Piperazine ring with a propanamine side chain, and a methyl and ethyl group substituted on the piperazine nitrogen atoms

Usage

Pharmaceutical intermediate with potential applications in drug development and research

Safety

Handle and use with care, following proper safety protocols and regulations to avoid potential hazards.

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 3490-06-0 N-methylhomoveratrylamine 

Relevant articles and documents

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.