1643489-24-0

Basic information

• Product Name: (+)-1,5-dimethyl-6-(2-methyl-4-([3-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 1643489-24-0
• Molecular Weight: 391.35
• Mol File: 1643489-24-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-1,5-dimethyl-6-(2-methyl-4-([3-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-1,5-dimethyl-6-(2-methyl-4-([3-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)pyrimidine-2,4(1H,3H)-dione(1643489-24-0)
• EPA Substance Registry System: (+)-1,5-dimethyl-6-(2-methyl-4-([3-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)pyrimidine-2,4(1H,3H)-dione(1643489-24-0)

Safety Data

• Hazardous Substances Data: 1643489-24-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "(+)-1,5-dimethyl-6-(2-methyl-4-([3-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)pyrimidine-2,4(1H,3H)-dione" is a pyrimidine derivative that contains a trifluoromethyl group and a pyridinyloxy moiety. Its molecular structure consists of a pyrimidine ring fused with a phenyl ring, and it has various methyl and fluorine substituents. (+)-1,5-dimethyl-6-(2-methyl-4-([3-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)pyrimidine-2,4(1H,3H)-dione may have potential applications in the pharmaceutical and agrochemical industries, as well as in research studies related to pyrimidine-based compounds with biological activities. Its precise properties, uses, and potential effects in biological systems would need to be further investigated and characterized in scientific studies.

Upstream product

• 1609259-61-1 6-bromo-1,5-dimethylpyrimidine-2,4(1H,3H)-dione 
• 1609259-60-0 6-amino-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, hydrochloride salt 
• 175205-82-0 2-bromo-3-(trifluoromethyl)-pyridine 
• 63959-47-7 6-amino-1,5-dimethylpyrimidine-2,4-(1H,3H)-dione 
• 14472-14-1 4-bromo-3-methylphenol 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 

Relevant articles and documents

Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent in Vivo Antiparkinsonian Activity

Dopamine receptors are important G protein-coupled receptors (GPCRs) with therapeutic opportunities for treating Parkinson's Disease (PD) motor and cognitive deficits. Biased D1 dopamine ligands that differentially activate G protein over β-arrestin recruitment pathways are valuable chemical tools for dissecting positive versus negative effects in drugs for PD. Here, we reveal an iterative approach toward modification of a D1-selective noncatechol scaffold critical for G protein-biased agonism. This approach provided enhanced understanding of the structural components critical for activity and signaling bias and led to the discovery of several novel compounds with useful pharmacological properties, including three highly GS-biased partial agonists. Administration of a potent, balanced, and brain-penetrant lead compound from this series results in robust antiparkinsonian effects in a rodent model of PD. This study suggests that the noncatechol ligands developed through this approach are valuable tools for probing D1 receptor signaling biology and biased agonism in models of neurologic disease.