16435-03-3

Basic information

• Product Name: Benzaldehyde, 4-hydroxy-, phenylhydrazone
• CAS NO: 16435-03-3
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• Mol File: 16435-03-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-hydroxy-, phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-hydroxy-, phenylhydrazone(16435-03-3)
• EPA Substance Registry System: Benzaldehyde, 4-hydroxy-, phenylhydrazone(16435-03-3)

Safety Data

• Hazardous Substances Data: 16435-03-3(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 
• 108-98-5 thiophenol 
• 58336-40-6 p-hydroxybenzaldehyde semicarbazone 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 

Downstream Products

• 2730-02-1 1,5-diphenyl-3-(trifluoromethyl)-1H-pyrazole 
• 97935-94-9 3-(4-Hydroxy-phenyl)-5-(4-methoxy-phenyl)-1-phenyl-1H-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 97935-85-8 3-(4-Hydroxy-phenyl)-5-(4-methoxy-phenyl)-1-phenyl-tetrahydro-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 97936-00-0 5-(4-Chloro-phenyl)-3-(4-hydroxy-phenyl)-1-phenyl-tetrahydro-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 97936-06-6 3-(4-Hydroxy-phenyl)-1,5-diphenyl-tetrahydro-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 13639-20-8 monopotassium para-hydroxybenzoate 
• 37097-17-9 14-(p-hydroxyphenyl)-14H-dibenzo[a,j]xanthene 
• 151358-47-3 3,3'-((4-hydroxyphenyl)methylene)bis(1H-indole) 
• 1448593-90-5 3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitrile 
• 1448594-06-6 5-(4-hydroxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole 
• 1448594-05-5 5-(3,4,5-trimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole 
• 1448594-04-4 5-(3,4-dimethoxyphenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole 
• 1448594-03-3 5-(4-chlorophenyl)-3-(3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,2,4-oxadiazole 
• 1448772-66-4 (Z)-N'-hydroxy-3-(4-hydroxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carboximidamide 

Relevant articles and documents

Efficient Method for Aromatic-Aldehyde Oxidation by Cleavage of Their Hydrazones Catalysed by Trimethylsilanolate

The reactions of hydrazones, derived from various aromatic aldehydes bound to Rink resin and hydrazines, with trimethylsilanolate have been studied. In this process, the aldehydes were oxidized to the corresponding carboxylic acids. The reaction was also tested with success in solution, with various aromatic aldehydes easily being oxidized in one pot via hydrazone formation and trimethylsilanolate treatment. A mechanism for the hydrazone cleavage is proposed. The reaction may be used as an alternative method for aldehyde oxidation with the selectivity complementary to that of currently used reactions.

Synthesis of and characterization of some Heterocyclic Compounds derived from Thiophenol

This research work involved preparation of heterogeneous pent lateral cyclic compounds (thiazolidine -4- one, benzothiazole, triazole, 4-oxothiazolidin) using thiophenol as raw materials: Thiophenol was reacted with mono chloroacetic acid in the presence of potassium hydroxide to prepare (sh1) followed by ortho amino aniline results the (sh2). The reaction of thiophenol with ethylchloroacetate afforded (sh3) and the reaction of (sh3) with thiosemicarbazide and 4% NaOH leads to ring closure giving 1,2,4- triazole (sh5). A treatment of thiophenol with hydrazine hydrate to obtain the intermediate (sh6) with aromatic aldehyde synthesized azomethines (sh7- sh9) then treated with mercaptoacetic acid to obtained (sh10-sh12). A treatment of thiophenol with chloroacetyl chloride produced (sh13) compound then treated with hydrazine hydrate to obtain (sh14) compound followed by bromobenzaldehyde synthesized azomethine (sh15) compound then treated with mercaptoacetic acid to obtained (sh16) compound. Characterization results for the prepared compounds using IR spectroscopy, NMR and melting points confirmed their chemical structures.

Lewis acid–catalyzed green synthesis and biological studies of pyrrolo[3,4-c]pyrazoles in aqueous medium

An environmentally benign approach in aqueous medium by means of Lewis acid catalyst affords a wide spectrum of pyrazoline derivatives in satisfactory yields. [3+2] cycloaddition reactions of substituted azomethine-N-imines to maleimide in aqueous medium at relatively high concentrations of Lewis acid catalyst have emerged as an environment friendly alternative to conventional solvents. Promising catalytic activity has been revealed by Lewis acid like Cu (NO3)2 in aqueous medium. The obvious features of this synthetic protocol were short reaction time, high efficiency, less hazardous synthesis by benign solvent, catalysis, modest workup, and a clean reaction methodology.